HitPredict

Interactor 1: DYN1 (P39055)
Dynamin (EC 3.6.5.5)
Gene: dyn-1

Interactor 2: TOCA1 (Q19253)
Transducer of Cdc42-dependent actin assembly protein 1 homolog
Gene: toca-1

Species: Caenorhabditis elegans

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	1.00	0.656

Property	Details
Experiments	23549480
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005886 - plasma membrane GO:0006897 - endocytosis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 830 Ce			1 592
+	Hs
		840723 DYN2_HUMAN (5-830): 0: 982: 63.05		FBP1L_HUMAN (5-588): 6.17e-92: 297: 23.92
+	Hs
		983403 DYN1_HUMAN (5-820): 0: 996: 62.07		FNBP1_HUMAN (5-588): 5.46e-82: 270: 25.12
+	Hs
		1301542 DYN3_HUMAN (5-830): 0: 987: 62.43		FNBP1_HUMAN (5-588): 5.46e-82: 270: 25.12
+	Hs
		840798 DYN2_HUMAN (5-830): 0: 982: 63.05		FNBP1_HUMAN (5-588): 5.46e-82: 270: 25.12
+	Hs
		840700 DYN2_HUMAN (5-830): 0: 982: 63.05		CIP4_HUMAN (5-588): 3.03e-79: 263: 21.70
+	Hs
		983392 DYN1_HUMAN (5-820): 0: 996: 62.07		NOSTN_HUMAN (4-381): 4.2e-58: 204: 15.18
+	Hs
		840753 DYN2_HUMAN (5-830): 0: 982: 63.05		FCSD1_HUMAN (12-588): 1.09e-48: 182: 13.91
+	Hs
		983417 DYN1_HUMAN (5-820): 0: 996: 62.07		PACN2_HUMAN (145-585): 2.97e-18: 89.9: 9.78
+	Mm
		1142989 DYN3_MOUSE (5-830): 0: 1001: 63.76		PACN1_MOUSE (181-585): 2.13e-16: 83.7: 7.86
+	Hs
		983406 DYN1_HUMAN (5-820): 0: 996: 62.07		PACN1_HUMAN (181-585): 1.6e-16: 84.1: 8.81
+	Mm
		760451 DYN1_MOUSE (5-826): 0: 995: 62.05		PACN1_MOUSE (181-585): 2.13e-16: 83.7: 7.86
+	Rn
		599414 DYN1_RAT (5-820): 0: 991: 62.31		PACN1_RAT (181-585): 1.37e-16: 84.5: 7.86
+	Mm
		760487 DYN2_MOUSE (5-830): 0: 986: 63.59		PACN2_MOUSE (111-585): 2.01e-17: 87.2: 10.25
+	Rn
		996551 DYN3_RAT (5-830): 0: 988: 62.66		PACN1_RAT (181-585): 1.37e-16: 84.5: 7.86
+	Hs
		983416 DYN1_HUMAN (5-820): 0: 996: 62.07		PACN3_HUMAN (249-585): 5.67e-14: 76: 10.53
+	Mm
		760475 DYN2_MOUSE (5-830): 0: 986: 63.59		PACN1_MOUSE (181-585): 2.13e-16: 83.7: 7.86
+	Mm
		760469 DYN1_MOUSE (5-826): 0: 995: 62.05		ITSN1_MOUSE (527-587): 1.47e-11: 69.7: 21.31
+	Mm
		760485 DYN2_MOUSE (5-830): 0: 986: 63.59		PACN3_MOUSE (249-585): 3e-13: 74.1: 10.23
+	Hs
		207784 DYN2_HUMAN (5-830): 0: 982: 63.05		PPIP1_HUMAN (211-585): 2.89e-14: 77.2: 11.52
+	Mm
		760488 DYN2_MOUSE (5-830): 0: 986: 63.59		ITSN1_MOUSE (527-587): 1.47e-11: 69.7: 21.31