HitPredict

Interactor 1: COIA1 (P39060)
Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1 (NC1)]
Gene: COL18A1

Interactor 2: COIA1 (P39060)
Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1 (NC1)]
Gene: COL18A1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.86 1.00 0.930

The method score is based on:

Property Details
Experiments 37071682, 11956183, 20932905, 9724722, 16269408
Identification Methods cross-linking study, circular dichroism, cosedimentation in solution, protein cross-linking with a bifunctional reagent, x-ray crystallography, classical fluorescence spectroscopy, electron microscopy, biophysical
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Collagen~Collagen, Collagen_trimer~Collagen_trimer, Endostatin~Endostatin, Fz~Fz
Common GO terms GO:0001501 - skeletal system development
GO:0001525 - angiogenesis
GO:0001886 - endothelial cell morphogenesis
GO:0005576 - extracellular region
GO:0005581 - collagen trimer
and 15 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 1754
Hs

1 1754
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024