HitPredict

Interactor 1: FYN (P39688)
Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene c-Fyn) (p59-Fyn)
Gene: FYN

Interactor 2: PHAG1 (Q3U1F9)
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane phosphoprotein Cbp)
Gene: Pag1

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.646

Property	Details
Experiments	26512138
Identification Methods	affinity chromatography technology
Interaction Type	association, physical association

Property	Details
Interacting Pfam domains	PAG~SH2
Common GO terms	GO:0002250 - adaptive immune response GO:0005886 - plasma membrane GO:0035556 - intracellular signal transduction GO:0045121 - membrane raft
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 537 Mm			1 429
+	Hs
		412375 FYN_HUMAN (1-537): 0: 634: 99.44		PHAG1_HUMAN (1-429): 0: 705: 78.21
+	Mm
		411925 LCK_MOUSE (74-535): 0: 548: 60.82		PHAG1_MOUSE (1-429): 0: 785: 100.00
+	Mm
		639443 LYN_MOUSE (1-535): 0: 530: 53.92		PHAG1_MOUSE (1-429): 0: 785: 100.00
+	Hs
		523175 SRC_HUMAN (1-537): 0: 592: 68.76		PHAG1_HUMAN (1-429): 0: 705: 78.21
+	Mm
		976830 ITK_MOUSE (5-526): 4.94e-173: 504: 32.90		PHAG1_MOUSE (1-429): 0: 785: 100.00
+	Mm
		782848 CSK_MOUSE (73-523): 1e-170: 492: 36.64		PHAG1_MOUSE (1-429): 0: 785: 100.00
+	Rn
		693647 CSK_RAT (73-525): 2.85e-172: 495: 36.44		PHAG1_RAT (1-429): 0: 764: 89.51
+	Hs
		411873 LCK_HUMAN (74-535): 0: 547: 61.04		PHAG1_HUMAN (1-429): 0: 705: 78.21
+	Hs
		434038 LYN_HUMAN (1-535): 0: 535: 54.48		PHAG1_HUMAN (1-429): 0: 705: 78.21
+	Hs
		337571 ABL1_HUMAN (43-537): 2.63e-169: 510: 39.84		PHAG1_HUMAN (1-429): 0: 705: 78.21
+	Hs
		789135 FRK_HUMAN (53-529): 3.43e-176: 507: 50.10		PHAG1_HUMAN (1-429): 0: 705: 78.21