HitPredict

Interactor 1: FYN (P39688)
Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene c-Fyn) (p59-Fyn)
Gene: FYN

Interactor 2: SH21C (Q45HK4)
SH2 domain-containing protein 1B2 (EAT-2-related transducer) (ERT) (EAT-2B)
Gene: Sh2d1b2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	16425036
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1
Common GO terms	GO:0002250 - adaptive immune response GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 537 Mm			1 132
+	Hs
		411936 FYN_HUMAN (1-537): 0: 634: 99.44		FYN_HUMAN (4-127): 1.51e-36: 132: 26.15
+	Hs
		411946 FYN_HUMAN (1-537): 0: 634: 99.44		YES_HUMAN (4-127): 2.82e-36: 131: 23.85
+	Hs
		412070 FYN_HUMAN (1-537): 0: 634: 99.44		ABL2_HUMAN (5-126): 3.99e-35: 129: 27.05
+	Hs
		337307 FYN_HUMAN (1-537): 0: 634: 99.44		ABL1_HUMAN (5-126): 9.52e-35: 128: 26.23
+	Hs
		411969 FYN_HUMAN (1-537): 0: 634: 99.44		SRC_HUMAN (4-127): 9.53e-35: 127: 26.92
+	Hs
		412071 FYN_HUMAN (1-537): 0: 634: 99.44		FRK_HUMAN (4-131): 5.07e-35: 127: 25.58
+	Hs
		411545 FYN_HUMAN (1-537): 0: 634: 99.44		LCK_HUMAN (4-127): 3.02e-34: 125: 26.92
+	Mm
		292397 FYN_MOUSE (1-537): 0: 633: 100.00		SH21A_MOUSE (6-121): 4.81e-37: 124: 37.93
+	Hs
		412066 FYN_HUMAN (1-537): 0: 634: 99.44		CSK_HUMAN (3-100): 4.11e-32: 119: 30.61
+	Hs
		243121 FYN_HUMAN (1-537): 0: 634: 99.44		SH21A_HUMAN (6-124): 1.35e-33: 115: 38.66
+	Hs
		155829 SRC_HUMAN (1-537): 0: 592: 68.76		SH21B_HUMAN (1-132): 2.75e-40: 132: 65.91
+	Mm
		403460 SRC_MOUSE (1-537): 0: 594: 68.52		SHIP1_MOUSE (4-132): 1e-34: 128: 30.23
+	Rn
		1376717 SRC_RAT (1-537): 0: 594: 68.33		SRC_RAT (4-127): 7.7e-35: 127: 26.92
+	Gg
		337663 SRC_CHICK (1-537): 0: 595: 68.28		SRC_CHICK (4-127): 1.22e-34: 126: 27.69
+	Mm
		403406 SRC_MOUSE (1-537): 0: 594: 68.52		SRC_MOUSE (4-127): 1.04e-34: 127: 26.92
+	Rn
		989767 SRC_RAT (1-537): 0: 594: 68.33		LYN_RAT (4-126): 7.53e-34: 124: 22.48
+	Rn
		693648 SRC_RAT (1-537): 0: 594: 68.33		CSK_RAT (3-100): 7.36e-33: 121: 31.63
+	Mm
		763393 FYN_MOUSE (1-537): 0: 633: 100.00		GRB2_MOUSE (4-87): 6.79e-19: 80.5: 32.14
+	Hs
		412076 FYN_HUMAN (1-537): 0: 634: 99.44		KSYK_HUMAN (3-128): 4.23e-16: 75.1: 25.98
+	Mm
		403423 SRC_MOUSE (1-537): 0: 594: 68.52		KSYK_MOUSE (3-128): 1e-14: 71.2: 25.20