HitPredict

Interactor 1: MPK1 (P39745)
Mitogen-activated protein kinase mpk-1 (EC 2.7.11.24) (MAP kinase sur-1)
Gene: mpk-1

Interactor 2: MEK2 (Q10664)
Dual specificity mitogen-activated protein kinase kinase mek-2 (MAP kinase kinase mek-2) (EC 2.7.12.2)
Gene: mek-2

Species: Caenorhabditis elegans

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.79 1.00 0.889

The method score is based on:

Property Details
Experiments 10615043, 18073423, 12679813, 14704431
Identification Methods two hybrid, enzymatic study, two hybrid array
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Pkinase~Pkinase
Common GO terms GO:0000165 - MAPK cascade
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0007265 - Ras protein signal transduction
GO:0016310 - phosphorylation
and 4 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 444
Ce

1 387
+ Ce
+ At
+ Hs
+ Mm
+ Hs
+ Xl
+ At
+ Xl
+ Dm
+ Hs
+ At
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

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Last updated: 15 Jul 2024