HitPredict

Interactor 1: MMP12 (P39900)
Macrophage metalloelastase (MME) (EC 3.4.24.65) (Macrophage elastase) (ME) (hME) (Matrix metalloproteinase-12) (MMP-12)
Gene: MMP12

Interactor 2: CXCL5 (P42830)
C-X-C motif chemokine 5 (ENA-78(1-78)) (Epithelial-derived neutrophil-activating protein 78) (Neutrophil-activating peptide ENA-78) (Small-inducible cytokine B5) [Cleaved into: ENA-78(8-78); ENA-78(9-78)]
Gene: CXCL5

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	18660381
Identification Methods	protease assay
Interaction Type	protein cleavage

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 470 Hs			1 114
+	Hs
		764727 MMP12_HUMAN (1-470): 0: 665: 100.00		CXCL6_HUMAN (1-114): 2.69e-34: 116: 79.83
+	Hs
		587770 MMP12_HUMAN (1-470): 0: 665: 100.00		CXCL2_HUMAN (38-112): 1.06e-27: 99.4: 46.67
+	Hs
		364043 MMP12_HUMAN (1-470): 0: 665: 100.00		CXCL7_HUMAN (43-114): 4.05e-27: 98.6: 50.00
+	Hs
		587787 MMP12_HUMAN (1-470): 0: 665: 100.00		CXCL3_HUMAN (43-112): 9.93e-27: 96.7: 51.43
+	Hs
		448989 MMP12_HUMAN (1-470): 0: 665: 100.00		GROA_HUMAN (43-112): 2.33e-26: 95.9: 50.00
+	Hs
		486188 MMP12_HUMAN (1-470): 0: 665: 100.00		IL8_HUMAN (44-113): 8.67e-24: 89: 36.62
+	Hs
		372733 MMP1_HUMAN (11-470): 0: 608: 49.24		CXCL5_HUMAN (1-114): 1.6e-39: 129: 100.00
+	Hs
		486190 MMP13_HUMAN (1-470): 0: 639: 45.80		IL8_HUMAN (44-113): 8.67e-24: 89: 36.62
+	Hs
		612139 MMP8_HUMAN (13-470): 0: 599: 47.16		CXCL5_HUMAN (1-114): 1.6e-39: 129: 100.00
+	Hs
		372737 MMP1_HUMAN (11-470): 0: 608: 49.24		CXCL6_HUMAN (1-114): 2.69e-34: 116: 79.83
+	Mm
		714630 MMP12_MOUSE (1-470): 0: 593: 61.78		CXCL5_MOUSE (1-113): 1.32e-38: 127: 51.28
+	Hs
		372731 MMP1_HUMAN (11-470): 0: 608: 49.24		CXCL2_HUMAN (38-112): 1.06e-27: 99.4: 46.67
+	Hs
		364034 MMP1_HUMAN (11-470): 0: 608: 49.24		CXCL7_HUMAN (43-114): 4.05e-27: 98.6: 50.00
+	Hs
		372724 MMP1_HUMAN (11-470): 0: 608: 49.24		IL8_HUMAN (44-113): 8.67e-24: 89: 36.62
+	Mm
		500671 MMP12_MOUSE (1-470): 0: 593: 61.78		CXCL2_MOUSE (38-112): 1.1e-28: 101: 49.33
+	Mm
		522396 MMP12_MOUSE (1-470): 0: 593: 61.78		GROA_MOUSE (39-109): 6.8e-28: 99.4: 53.52
+	Mm
		714631 MMP12_MOUSE (1-470): 0: 593: 61.78		CXCL3_MOUSE (38-113): 2.95e-27: 97.8: 43.42
+	Hs
		486182 MMP8_HUMAN (13-470): 0: 599: 47.16		IL8_HUMAN (44-113): 8.67e-24: 89: 36.62
+	Hs
		364037 MMP9_HUMAN (12-206): 2.35e-72: 243: 36.77		CXCL7_HUMAN (43-114): 4.05e-27: 98.6: 50.00
+	Hs
		486175 MMP9_HUMAN (12-206): 2.35e-72: 243: 36.77		IL8_HUMAN (44-113): 8.67e-24: 89: 36.62