HitPredict

Interactor 1: AFG3 (P39925)
Mitochondrial inner membrane m-AAA protease component YTA10 (EC 3.4.24.-) (EC 3.6.-.-) (ATPase family gene 3 protein) (Tat-binding homolog 10)
Gene: AFG3

Interactor 2: PHB2 (P50085)
Prohibitin-2
Gene: PHB2

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	16429126, 37968396, 16239145
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0005743 - mitochondrial inner membrane
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 761 Sc			1 310
+	Sc
		764773 AFG3_YEAST (1-761): 0: 630: 100.00		PHB1_YEAST (37-293): 1.61e-85: 260: 55.04
+	Hs
		1305325 AFG32_HUMAN (1-756): 0: 549: 45.06		PHB2_HUMAN (22-309): 1.28e-98: 293: 51.72
+	Hs
		719266 AFG32_HUMAN (1-756): 0: 549: 45.06		PHB1_HUMAN (39-297): 2.95e-89: 269: 50.00
+	At
		1258446 FTSHA_ARATH (3-735): 6.91e-179: 534: 44.49		PHB2_ARATH (27-289): 1.03e-90: 273: 54.75
+	At
		1258445 FTSHA_ARATH (3-735): 6.91e-179: 534: 44.49		PHB6_ARATH (27-289): 2.09e-90: 272: 52.85
+	At
		138214 FTSHA_ARATH (3-735): 6.91e-179: 534: 44.49		PHB3_ARATH (28-297): 2.36e-88: 267: 50.55
+	Sc
		772371 YTA12_YEAST (22-747): 3.09e-167: 504: 52.52		PHB2_YEAST (1-310): 7.61e-100: 297: 100.00
+	At
		221625 FTSHA_ARATH (3-735): 6.91e-179: 534: 44.49		PHB1_ARATH (26-289): 4.68e-88: 266: 53.18
+	Sc
		772369 YTA12_YEAST (22-747): 3.09e-167: 504: 52.52		PHB1_YEAST (37-293): 1.61e-85: 260: 55.04
+	Hs
		1303088 YMEL1_HUMAN (160-737): 2.62e-131: 410: 32.99		PHB2_HUMAN (22-309): 1.28e-98: 293: 51.72