HitPredict

Interactor 1: RSP5 (P39940)
E3 ubiquitin-protein ligase RSP5 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase RSP5) (Reverses SPT-phenotype protein 5)
Gene: RSP5

Interactor 2: MGA2 (P40578)
Protein MGA2
Gene: MGA2

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	0.60	0.741

Property	Details
Experiments	15466864, 17719829, 12867034, 26508657, 19153599, 17289586
Identification Methods	pull down, affinity chromatography technology, enzymatic study
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 809 Sc			1 1113
+	Sc
		716539 RSP5_YEAST (1-809): 0: 825: 100.00		SPT23_YEAST (128-1113): 0: 642: 37.24
+	Hs
		1043731 ITCH_HUMAN (1-809): 0: 727: 34.62		ASPP2_HUMAN (339-787): 1.51e-72: 264: 14.29
+	Hs
		125441 WWP2_HUMAN (100-809): 0: 684: 40.81		ASPP2_HUMAN (339-787): 1.51e-72: 264: 14.29
+	Hs
		808118 NEDD4_HUMAN (102-807): 0: 668: 39.67		ASPP2_HUMAN (339-787): 1.51e-72: 264: 14.29
+	Hs
		808103 NEDD4_HUMAN (102-807): 0: 668: 39.67		Q05BL1_HUMAN (339-787): 7.72e-72: 261: 14.29
+	Hs
		125040 WWP2_HUMAN (100-809): 0: 684: 40.81		ANR17_HUMAN (541-1033): 1.52e-56: 217: 11.11
+	Hs
		1336115 SMUF1_HUMAN (4-809): 0: 701: 36.64		ANR50_HUMAN (701-961): 6.24e-49: 192: 14.15
+	Hs
		125583 WWP2_HUMAN (100-809): 0: 684: 40.81		ANR44_HUMAN (450-855): 5.51e-49: 191: 9.82
+	Hs
		808109 NEDD4_HUMAN (102-807): 0: 668: 39.67		ANK3_HUMAN (622-1019): 3.6e-53: 207: 11.98
+	Hs
		125054 WWP2_HUMAN (100-809): 0: 684: 40.81		PSD10_HUMAN (637-840): 9.44e-14: 73.7: 15.53