HitPredict

Interactor 1: RSP5 (P39940)
E3 ubiquitin-protein ligase RSP5 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase RSP5) (Reverses SPT-phenotype protein 5)
Gene: RSP5

Interactor 2: UBC13 (P52490)
Ubiquitin-conjugating enzyme E2 13 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme 13) (Ubiquitin carrier protein 13) (Ubiquitin-protein ligase 13)
Gene: UBC13

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	26508657
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HECT~UQ_con
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0070534 - protein K63-linked ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 809 Sc			1 153
+	Sc
		549815 RSP5_YEAST (1-809): 0: 825: 100.00		UBC4_YEAST (1-148): 5.55e-79: 231: 49.32
+	Sc
		549857 RSP5_YEAST (1-809): 0: 825: 100.00		UBC5_YEAST (1-148): 2.07e-78: 230: 49.32
+	Hs
		1294888 ITCH_HUMAN (1-809): 0: 727: 34.62		UB2D4_HUMAN (4-149): 5.02e-80: 234: 48.63
+	Sp
		145419 PUB3_SCHPO (4-809): 0: 733: 54.05		UBC4_SCHPO (4-148): 1.02e-77: 228: 48.28
+	Hs
		849411 ITCH_HUMAN (1-809): 0: 727: 34.62		UB2D1_HUMAN (4-149): 5.48e-79: 231: 47.95
+	Hs
		919827 ITCH_HUMAN (1-809): 0: 727: 34.62		UB2D2_HUMAN (4-149): 5.61e-79: 231: 47.95
+	Hs
		895882 ITCH_HUMAN (1-809): 0: 727: 34.62		UB2D3_HUMAN (4-149): 6.61e-78: 229: 47.26
+	Hs
		1282329 ITCH_HUMAN (1-809): 0: 727: 34.62		UB2E3_HUMAN (1-149): 7.79e-74: 221: 46.98
+	Hs
		1294835 ITCH_HUMAN (1-809): 0: 727: 34.62		UB2E2_HUMAN (1-149): 4.72e-74: 221: 46.98
+	Hs
		851871 ITCH_HUMAN (1-809): 0: 727: 34.62		UB2E1_HUMAN (1-149): 2.68e-72: 216: 46.31
+	Hs
		849452 SMUF1_HUMAN (4-809): 0: 701: 36.64		UB2D1_HUMAN (4-149): 5.48e-79: 231: 47.95
+	Hs
		919869 SMUF1_HUMAN (4-809): 0: 701: 36.64		UB2D2_HUMAN (4-149): 5.61e-79: 231: 47.95
+	Hs
		895919 SMUF1_HUMAN (4-809): 0: 701: 36.64		UB2D3_HUMAN (4-149): 6.61e-78: 229: 47.26
+	Hs
		849444 WWP1_HUMAN (108-809): 0: 690: 40.33		UB2D1_HUMAN (4-149): 5.48e-79: 231: 47.95
+	Hs
		919860 WWP1_HUMAN (108-809): 0: 690: 40.33		UB2D2_HUMAN (4-149): 5.61e-79: 231: 47.95
+	Hs
		895910 WWP1_HUMAN (108-809): 0: 690: 40.33		UB2D3_HUMAN (4-149): 6.61e-78: 229: 47.26
+	Hs
		125262 WWP2_HUMAN (100-809): 0: 684: 40.81		UB2D1_HUMAN (4-149): 5.48e-79: 231: 47.95
+	Hs
		125335 WWP2_HUMAN (100-809): 0: 684: 40.81		UB2D2_HUMAN (4-149): 5.61e-79: 231: 47.95
+	Hs
		125300 WWP2_HUMAN (100-809): 0: 684: 40.81		UB2D3_HUMAN (4-149): 6.61e-78: 229: 47.26
+	Hs
		125263 WWP2_HUMAN (100-809): 0: 684: 40.81		UB2E1_HUMAN (1-149): 2.68e-72: 216: 46.31