HitPredict

Interactor 1: CAP2 (P40123)
Adenylyl cyclase-associated protein 2 (CAP 2)
Gene: CAP2

Interactor 2: ACTG (P63261)
Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed]
Gene: ACTG1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	1.00	0.958

Property	Details
Experiments	32296183, 8761950, 25416956, 25910212, 35271311, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid, split luciferase complementation, two hybrid bait and prey pooling approach, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Actin~CAP_C
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 477 Hs			1 375
+	Hs
		768478 CAP2_HUMAN (1-477): 0: 698: 100.00		ACTBL_HUMAN (2-375): 0: 734: 91.44
+	Hs
		965194 CAP1_HUMAN (1-475): 0: 651: 62.71		ACTBL_HUMAN (2-375): 0: 734: 91.44
+	Hs
		768462 CAP2_HUMAN (1-477): 0: 698: 100.00		ACTB_HUMAN (1-375): 0: 604: 98.93
+	Hs
		768474 CAP2_HUMAN (1-477): 0: 698: 100.00		Q1KLZ0_HUMAN (1-375): 0: 604: 98.93
+	Hs
		768467 CAP2_HUMAN (1-477): 0: 698: 100.00		ACTC_HUMAN (2-375): 0: 595: 94.39
+	Hs
		768465 CAP2_HUMAN (1-477): 0: 698: 100.00		ACTA_HUMAN (2-375): 0: 594: 94.39
+	Hs
		768468 CAP2_HUMAN (1-477): 0: 698: 100.00		ACTS_HUMAN (2-375): 0: 594: 93.85
+	Hs
		891700 CAP1_HUMAN (1-475): 0: 651: 62.71		ACTB_HUMAN (1-375): 0: 604: 98.93
+	Hs
		929826 CAP1_HUMAN (1-475): 0: 651: 62.71		ACTG_HUMAN (1-375): 0: 604: 100.00
+	Hs
		932109 CAP1_HUMAN (1-475): 0: 651: 62.71		ACTC_HUMAN (2-375): 0: 595: 94.39
+	Hs
		915363 CAP1_HUMAN (1-475): 0: 651: 62.71		ACTA_HUMAN (2-375): 0: 594: 94.39
+	Hs
		932956 CAP1_HUMAN (1-475): 0: 651: 62.71		ACTS_HUMAN (2-375): 0: 594: 93.85
+	Dm
		501544 Q9VPX7_DROME (45-474): 0: 552: 48.03		ACT1_DROME (2-375): 0: 600: 98.13
+	Dm
		501500 Q7KN55_DROME (4-474): 0: 551: 43.52		ACT1_DROME (2-375): 0: 600: 98.13
+	Dm
		361155 Q9VPX7_DROME (45-474): 0: 552: 48.03		ACT2_DROME (2-375): 0: 598: 97.59
+	Dm
		501543 Q9VPX6_DROME (4-474): 0: 527: 43.73		ACT1_DROME (2-375): 0: 600: 98.13
+	Sp
		501577 CAP_SCHPO (14-473): 0: 532: 33.40		ACT_SCHPO (1-375): 0: 594: 91.47
+	Dm
		361154 Q9VPX6_DROME (4-474): 0: 527: 43.73		ACT2_DROME (2-375): 0: 598: 97.59
+	Dm
		501456 Q9VPX6_DROME (4-474): 0: 527: 43.73		ACT5_DROME (2-375): 0: 598: 95.46
+	Dm
		361193 Q9VPX6_DROME (4-474): 0: 527: 43.73		ACT4_DROME (2-375): 0: 592: 94.65