Interactor 1: IL6RB (P40189)
Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (CDw130) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)
Gene: IL6ST

Interactor 2: IL6RB (P40189)
Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (CDw130) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)
Gene: IL6ST

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.68 1.00 0.827

The method score is based on:

Property Details
Experiments 8940087, 19020503, 24501689
Identification Methods anti tag coimmunoprecipitation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains fn3~fn3, IL6Ra-bind~fn3, IL6Ra-bind~IL6Ra-bind, IL6Ra-bind~Lep_receptor_Ig
Common GO terms GO:0002675 - positive regulation of acute inflammatory response
GO:0002821 - positive regulation of adaptive immune response
GO:0004896 - cytokine receptor activity
GO:0004897 - ciliary neurotrophic factor receptor activity
GO:0004915 - interleukin-6 receptor activity
and 46 others

more...

Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 918
Hs

1 918
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+ Dm

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Last updated: 15 Jul 2024