Interactor 1: IL6RB (P40189)
Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (CDw130) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)
Gene: IL6ST

Interactor 2: LIFR (P42702)
Leukemia inhibitory factor receptor (LIF receptor) (LIF-R) (CD antigen CD118)
Gene: LIFR

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.56 1.00 0.754

The method score is based on:

Property Details
Experiments 12047380, 8999038
Identification Methods affinity chromatography technology
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains fn3~fn3, IL6Ra-bind~fn3
Common GO terms GO:0004896 - cytokine receptor activity
GO:0005127 - ciliary neurotrophic factor receptor binding
GO:0005886 - plasma membrane
GO:0008284 - positive regulation of cell population proliferation
GO:0009897 - external side of plasma membrane
and 9 others

more...

Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 918
Hs

1 1097
+ Mm
+ Mm
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+ Mm
+ Mm
+ Hs
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+ Hs
+ Hs
+ Dm
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024