HitPredict

Interactor 1: IL6RB (P40189)
Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (CDw130) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)
Gene: IL6ST

Interactor 2: PTN11 (Q06124)
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
Gene: PTPN11

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	1.00	0.909

Property	Details
Experiments	9794795, 12403768, 10946280, 9388212, 10777583
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	SH2~fn3
Common GO terms	GO:0019221 - cytokine-mediated signaling pathway
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 918 Hs			1 593
+	Hs
		665811 IL6RB_HUMAN (1-918): 0: 623: 100.00		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Mm
		719297 IL6RB_MOUSE (1-918): 0: 574: 77.04		PTN11_MOUSE (1-593): 0: 580: 99.49
+	Hs
		986020 CSF3R_HUMAN (1-818): 1.84e-103: 342: 24.91		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		560475 PRLR_HUMAN (124-351): 1.32e-50: 190: 25.83		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		489957 PTPRF_HUMAN (32-733): 1.82e-83: 296: 14.38		PTPRS_HUMAN (39-522): 8.52e-117: 384: 26.76
+	Hs
		265768 CRLF1_HUMAN (31-395): 5.82e-86: 283: 24.93		PTPRS_HUMAN (39-522): 8.52e-117: 384: 26.76
+	Hs
		489886 PTPRF_HUMAN (32-733): 1.82e-83: 296: 14.38		PTPRF_HUMAN (33-522): 2.6e-112: 371: 25.85
+	Hs
		1031977 PTPRS_HUMAN (22-914): 1.28e-78: 282: 11.66		PTPRS_HUMAN (39-522): 8.52e-117: 384: 26.76
+	Hs
		616916 PTPRS_HUMAN (22-914): 1.28e-78: 282: 11.66		PTPRB_HUMAN (147-555): 2.35e-115: 379: 27.91
+	Hs
		616971 PTPRS_HUMAN (22-914): 1.28e-78: 282: 11.66		PTPRD_HUMAN (39-522): 2.1e-115: 379: 26.76
+	Hs
		490002 PTPRF_HUMAN (32-733): 1.82e-83: 296: 14.38		PTPR2_HUMAN (135-531): 5.92e-113: 362: 30.15
+	Mm
		56906 PTPRF_MOUSE (32-733): 3.86e-85: 301: 15.40		PTPRA_MOUSE (33-522): 1.27e-110: 351: 23.52
+	Hs
		616939 PTPRD_HUMAN (1-897): 2.19e-59: 223: 11.86		PTPRD_HUMAN (39-522): 2.1e-115: 379: 26.76
+	Mm
		574008 PTPRD_MOUSE (1-702): 1.76e-58: 221: 12.82		PTPRA_MOUSE (33-522): 1.27e-110: 351: 23.52
+	Dm
		561767 LAR_DROME (115-849): 8.92e-58: 219: 11.42		LAR_DROME (40-522): 8.91e-102: 341: 24.55
+	Mm
		828098 PTPRD_MOUSE (1-702): 1.76e-58: 221: 12.82		PTPRE_MOUSE (33-522): 3.96e-102: 326: 22.88
+	Gg
		47583 CNTN1_CHICK (8-915): 4.99e-48: 187: 9.76		A0A8V0YWD3_CHICK (33-522): 1.95e-110: 353: 24.25
+	Hs
		489902 PTPRF_HUMAN (32-733): 1.82e-83: 296: 14.38		PTPRZ_HUMAN (33-537): 1.15e-65: 235: 16.73