HitPredict

Interactor 1: IL6RB (P40189)
Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (CDw130) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)
Gene: IL6ST

Interactor 2: FBX2 (Q9UK22)
F-box only protein 2
Gene: FBXO2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.50	0.583

Property	Details
Experiments	32549792, 33961781
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 918 Hs			1 296
+	Hs
		1305437 OSMR_HUMAN (30-841): 8.5e-104: 347: 19.17		FBX2_HUMAN (1-296): 5.13e-147: 416: 100.00
+	Hs
		265802 CRLF1_HUMAN (31-395): 5.82e-86: 283: 24.93		FBX2_HUMAN (1-296): 5.13e-147: 416: 100.00
+	Hs
		1032042 PTPRS_HUMAN (22-914): 1.28e-78: 282: 11.66		FBX2_HUMAN (1-296): 5.13e-147: 416: 100.00
+	Hs
		1032034 PTPRS_HUMAN (22-914): 1.28e-78: 282: 11.66		FBX6_HUMAN (40-296): 2.4e-133: 381: 49.81
+	Hs
		1356264 ROBO1_HUMAN (6-512): 1.04e-51: 199: 11.25		FBX2_HUMAN (1-296): 5.13e-147: 416: 100.00
+	Hs
		1018314 CNTN1_HUMAN (27-915): 3.52e-47: 184: 9.82		FBX2_HUMAN (1-296): 5.13e-147: 416: 100.00
+	Hs
		789685 LIFR_HUMAN (127-619): 3.5e-24: 111: 13.30		FBX2_HUMAN (1-296): 5.13e-147: 416: 100.00
+	Hs
		685328 L1CAM_HUMAN (121-918): 4.49e-22: 105: 10.00		FBX2_HUMAN (1-296): 5.13e-147: 416: 100.00
+	Hs
		1123262 SDK2_HUMAN (242-918): 1.61e-20: 100: 10.01		FBX2_HUMAN (1-296): 5.13e-147: 416: 100.00
+	Hs
		817334 LEPR_HUMAN (295-801): 5.68e-14: 78.5: 12.94		FBX2_HUMAN (1-296): 5.13e-147: 416: 100.00
+	Hs
		789684 LIFR_HUMAN (127-619): 3.5e-24: 111: 13.30		FBX6_HUMAN (40-296): 2.4e-133: 381: 49.81
+	Hs
		685320 L1CAM_HUMAN (121-918): 4.49e-22: 105: 10.00		FBX6_HUMAN (40-296): 2.4e-133: 381: 49.81
+	Hs
		817333 LEPR_HUMAN (295-801): 5.68e-14: 78.5: 12.94		FBX6_HUMAN (40-296): 2.4e-133: 381: 49.81