HitPredict

Interactor 1: TCPZ (P40227)
T-complex protein 1 subunit zeta (TCP-1-zeta) (Acute morphine dependence-related protein 2) (CCT-zeta-1) (Chaperonin containing T-complex polypeptide 1 subunit 6A) (HTR3) (Tcp20)
Gene: CCT6A

Interactor 2: FBXW4 (P57775)
F-box/WD repeat-containing protein 4 (Dactylin) (F-box and WD-40 domain-containing protein 4)
Gene: FBXW4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 531 Hs			1 412
+	Hs
		885053 TCPH_HUMAN (2-530): 0: 576: 27.93		FBXW4_HUMAN (21-412): 3.66e-83: 262: 98.22
+	Hs
		771090 TCPZ_HUMAN (1-531): 0: 573: 100.00		FBW1B_HUMAN (34-411): 3.49e-81: 260: 16.03
+	Hs
		826588 TCPG_HUMAN (3-528): 0: 559: 27.96		FBXW4_HUMAN (21-412): 3.66e-83: 262: 98.22
+	Hs
		903467 TCPH_HUMAN (2-530): 0: 576: 27.93		WDR5_HUMAN (1-319): 1.97e-65: 213: 12.61
+	Hs
		770771 TCPZ_HUMAN (1-531): 0: 573: 100.00		WDR5_HUMAN (1-319): 1.97e-65: 213: 12.61
+	Hs
		1202777 TCPH_HUMAN (2-530): 0: 576: 27.93		WDR5B_HUMAN (33-319): 2.7e-61: 203: 12.80
+	Hs
		792942 TCPG_HUMAN (3-528): 0: 559: 27.96		LIS1_HUMAN (7-322): 9.15e-67: 219: 13.20
+	Hs
		770916 TCPZ_HUMAN (1-531): 0: 573: 100.00		WDR5B_HUMAN (33-319): 2.7e-61: 203: 12.80
+	Hs
		770968 TCPZ_HUMAN (1-531): 0: 573: 100.00		FBXW7_HUMAN (24-276): 1.51e-43: 163: 14.89
+	Hs
		1240450 TCPH_HUMAN (2-530): 0: 576: 27.93		POC1A_HUMAN (22-227): 1.35e-37: 142: 11.27
+	Hs
		770932 TCPZ_HUMAN (1-531): 0: 573: 100.00		POC1A_HUMAN (22-227): 1.35e-37: 142: 11.27
+	Hs
		1306654 TCPH_HUMAN (2-530): 0: 576: 27.93		KTNB1_HUMAN (100-275): 1.19e-32: 132: 15.47
+	Hs
		771018 TCPZ_HUMAN (1-531): 0: 573: 100.00		KTNB1_HUMAN (100-275): 1.19e-32: 132: 15.47
+	Hs
		1198554 TCPH_HUMAN (2-530): 0: 576: 27.93		WDR86_HUMAN (153-399): 2.12e-22: 99.5: 17.74
+	Hs
		770911 TCPZ_HUMAN (1-531): 0: 573: 100.00		WDR86_HUMAN (153-399): 2.12e-22: 99.5: 17.74
+	Hs
		1306704 TCPH_HUMAN (2-530): 0: 576: 27.93		NLE1_HUMAN (328-411): 2.65e-17: 85.6: 11.91
+	Hs
		771069 TCPZ_HUMAN (1-531): 0: 573: 100.00		NLE1_HUMAN (328-411): 2.65e-17: 85.6: 11.91
+	Hs
		770974 TCPZ_HUMAN (1-531): 0: 573: 100.00		SNR40_HUMAN (322-411): 5.98e-14: 74.5: 14.29
+	Hs
		1306744 TCPH_HUMAN (2-530): 0: 576: 27.93		FBW1A_HUMAN (39-151): 6.54e-10: 62.9: 10.83
+	Hs
		771097 TCPZ_HUMAN (1-531): 0: 573: 100.00		FBW1A_HUMAN (39-151): 6.54e-10: 62.9: 10.83