HitPredict

Interactor 1: PSA2 (P40301)
Proteasome subunit alpha type-2 (PROS-Dm25) (Proteasome 25 kDa subunit)
Gene: Prosalpha2

Interactor 2: Q7K148 (Q7K148)
Proteasome subunit beta
Gene: Prosbeta5

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.904

Property	Details
Experiments	23457214, 23738891, 31002009, 22036573, 19079254
Identification Methods	affinity chromatography technology, two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Proteasome~Proteasome, Proteasome~Proteasome_A_N
Common GO terms	GO:0000502 - proteasome complex GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0005839 - proteasome core complex GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 234 Dm			1 282
+	Dm
		1178944 PSA5_DROME (1-233): 1.55e-97: 286: 30.71		Q7K148_DROME (1-282): 5.42e-104: 305: 100.00
+	Sp
		293714 PSA2_SCHPO (3-233): 1.96e-107: 311: 58.20		PSA3_SCHPO (43-278): 9.22e-88: 263: 16.60
+	Hs
		656152 PSA5_HUMAN (1-233): 1.45e-98: 288: 31.38		PSB5_HUMAN (1-273): 8.79e-89: 266: 52.38
+	Hs
		656149 PSA5_HUMAN (1-233): 1.45e-98: 288: 31.38		PSA5_HUMAN (41-272): 1.3e-88: 265: 18.60
+	Hs
		156230 PSA5_HUMAN (1-233): 1.45e-98: 288: 31.38		PSA7_HUMAN (46-269): 2.53e-85: 257: 15.95
+	Hs
		638067 PSA5_HUMAN (1-233): 1.45e-98: 288: 31.38		PSA4_HUMAN (43-269): 9.16e-85: 256: 17.30
+	Hs
		656164 PSA5_HUMAN (1-233): 1.45e-98: 288: 31.38		PSB10_HUMAN (47-256): 3.95e-83: 252: 29.05
+	Hv
		1358195 PSA1_HALVD (6-232): 6.99e-96: 282: 36.25		PSA1_HALVD (46-281): 1.85e-85: 257: 17.89
+	Sp
		675393 PSA5_SCHPO (1-231): 3.4e-100: 293: 32.77		PSB5_SCHPO (46-277): 2.52e-80: 245: 53.88
+	Ce
		1099874 PSA2_CAEEL (4-233): 3.6e-99: 289: 60.35		PBS5_CAEEL (44-276): 4.74e-80: 245: 45.00
+	Mt
		191406 PSA_METTH (1-233): 1.2e-102: 299: 36.17		PSB_METTH (72-267): 2.66e-75: 230: 36.04
+	Hs
		656296 PSA5_HUMAN (1-233): 1.45e-98: 288: 31.38		PSB7_HUMAN (39-265): 6.52e-77: 236: 28.63
+	Af
		191426 PSA_ARCFU (5-231): 5.1e-97: 285: 40.18		PSB_ARCFU (65-274): 1.66e-77: 235: 32.23
+	Hs
		656276 PSA5_HUMAN (1-233): 1.45e-98: 288: 31.38		PSMA8_HUMAN (43-269): 1.37e-75: 232: 17.08
+	Dm
		1278650 PSA5_DROME (1-233): 1.55e-97: 286: 30.71		Q9VUJ1_DROME (47-267): 1.41e-75: 233: 27.60
+	Hs
		656151 PSA5_HUMAN (1-233): 1.45e-98: 288: 31.38		PSB6_HUMAN (69-259): 3.57e-73: 225: 30.21
+	Mm
		1154361 PSA_METMP (4-233): 8.01e-99: 290: 34.05		PSB_METMP (73-256): 1.17e-25: 102: 33.87
+	Ph
		223381 PSA_PYRHO (4-231): 1.88e-101: 296: 41.74		PSB1_PYRHO (68-256): 3.01e-20: 87.8: 30.53
+	Hs
		656090 PSA5_HUMAN (1-233): 1.45e-98: 288: 31.38		PSB9_HUMAN (73-256): 2.23e-19: 85.9: 30.98
+	Dm
		47610 PSA5_DROME (1-233): 1.55e-97: 286: 30.71		A0AQH0_DROME (73-256): 1.52e-18: 84: 29.57