HitPredict

Interactor 1: PSA6 (P40302)
Proteasome subunit alpha type-6 (Macropain subunit PRE5) (Multicatalytic endopeptidase complex subunit PRE5) (Proteasome component PRE5) (Proteinase YSCE subunit PRE5)
Gene: PRE5

Interactor 2: RPN8 (Q08723)
26S proteasome regulatory subunit RPN8
Gene: RPN8

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.691

Property	Details
Experiments	11805826, 19412159, 37968396, 16429126
Identification Methods	tandem affinity purification, affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0034515 - proteasome storage granule GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 234 Sc			1 338
+	Hs
		637651 PSA2_HUMAN (1-234): 6.67e-103: 299: 28.81		PSMD7_HUMAN (6-301): 2.63e-97: 292: 50.51
+	Dm
		522480 PSA1_DROME (1-234): 5.39e-94: 278: 46.64		PSMD7_DROME (4-325): 8.23e-103: 307: 45.68
+	Dm
		640776 PSA5_DROME (1-234): 5.2e-93: 274: 31.28		PSMD7_DROME (4-325): 8.23e-103: 307: 45.68
+	Dm
		574013 PSA4_DROME (1-234): 3.49e-89: 265: 30.71		PSMD7_DROME (4-325): 8.23e-103: 307: 45.68
+	Hs
		637362 PSA1_HUMAN (1-234): 2.47e-94: 278: 52.77		PSMD7_HUMAN (6-301): 2.63e-97: 292: 50.51
+	Mm
		643130 PSA1_MOUSE (1-234): 2.26e-94: 278: 52.77		PSMD7_MOUSE (6-301): 3.65e-97: 292: 50.51
+	Hs
		656177 PSA5_HUMAN (1-234): 3.29e-92: 272: 30.71		PSMD7_HUMAN (6-301): 2.63e-97: 292: 50.51
+	Hs
		638089 PSA4_HUMAN (1-234): 1.89e-91: 271: 31.95		PSMD7_HUMAN (6-301): 2.63e-97: 292: 50.51
+	Hs
		849173 PSA6_HUMAN (1-234): 2.43e-89: 265: 24.79		PSMD7_HUMAN (6-301): 2.63e-97: 292: 50.51
+	Sp
		145195 PSA6_SCHPO (1-226): 1.45e-94: 279: 61.67		RPN11_SCHPO (1-263): 3.34e-61: 199: 19.11
+	Sp
		784781 PSA5_SCHPO (1-234): 1.9e-94: 278: 32.23		RPN11_SCHPO (1-263): 3.34e-61: 199: 19.11
+	Sc
		689214 PSA5_YEAST (3-234): 1.78e-32: 120: 34.44		RPN8_YEAST (1-338): 6.52e-119: 348: 100.00
+	Dm
		522502 PSA1_DROME (1-234): 5.39e-94: 278: 46.64		PSDE_DROME (3-264): 6.45e-48: 165: 16.90
+	Dm
		1278634 PSA5_DROME (1-234): 5.2e-93: 274: 31.28		PSDE_DROME (3-264): 6.45e-48: 165: 16.90
+	Dm
		574029 PSA4_DROME (1-234): 3.49e-89: 265: 30.71		PSDE_DROME (3-264): 6.45e-48: 165: 16.90
+	Sp
		784767 PSA3_SCHPO (5-220): 9.62e-31: 115: 34.55		RPN11_SCHPO (1-263): 3.34e-61: 199: 19.11