HitPredict

Interactor 1: PSA4 (P40303)
Proteasome subunit alpha type-4 (Macropain subunit PRE6) (Multicatalytic endopeptidase complex subunit PRE6) (Proteasome component PRE6) (Proteinase YSCE subunit PRE6)
Gene: PRE6

Interactor 2: RPN5 (Q12250)
26S proteasome regulatory subunit RPN5 (Proteasome non-ATPase subunit 5)
Gene: RPN5

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	37968396, 21289098, 16429126, 24225956
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0034515 - proteasome storage granule GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 254 Sc			1 445
+	Hs
		121892 PSA7_HUMAN (4-234): 3.74e-95: 280: 58.01		PSD12_HUMAN (7-443): 3.17e-131: 387: 40.45
+	Hs
		121938 PSA4_HUMAN (3-233): 8.68e-91: 270: 31.49		PSD12_HUMAN (7-443): 3.17e-131: 387: 40.45
+	Hs
		121979 PSA6_HUMAN (2-239): 6.82e-91: 270: 29.75		PSD12_HUMAN (7-443): 3.17e-131: 387: 40.45
+	Hs
		121935 PSA1_HUMAN (2-249): 6.06e-90: 268: 31.35		PSD12_HUMAN (7-443): 3.17e-131: 387: 40.45
+	Hs
		121942 PSA5_HUMAN (2-236): 2.2e-90: 268: 32.92		PSD12_HUMAN (7-443): 3.17e-131: 387: 40.45
+	Hs
		121635 PSA7_HUMAN (4-234): 3.74e-95: 280: 58.01		PSD11_HUMAN (20-435): 2.54e-93: 289: 12.68
+	Hs
		893638 PSA6_HUMAN (2-239): 6.82e-91: 270: 29.75		CSN2_HUMAN (17-426): 1.57e-95: 296: 13.27
+	Hs
		121685 PSA4_HUMAN (3-233): 8.68e-91: 270: 31.49		PSD11_HUMAN (20-435): 2.54e-93: 289: 12.68
+	Hs
		121719 PSA6_HUMAN (2-239): 6.82e-91: 270: 29.75		PSD11_HUMAN (20-435): 2.54e-93: 289: 12.68
+	Hs
		121683 PSA1_HUMAN (2-249): 6.06e-90: 268: 31.35		PSD11_HUMAN (20-435): 2.54e-93: 289: 12.68
+	Hs
		121689 PSA5_HUMAN (2-236): 2.2e-90: 268: 32.92		PSD11_HUMAN (20-435): 2.54e-93: 289: 12.68
+	Dm
		1180708 PSA5_DROME (2-237): 3.02e-91: 270: 31.28		PSD11_DROME (21-435): 1.22e-90: 282: 12.41
+	Sp
		1013779 PSA4_SCHPO (1-252): 1.7e-93: 277: 55.95		RPN6_SCHPO (25-432): 2.33e-86: 272: 12.95
+	Dm
		611643 PSA71_DROME (2-233): 1.09e-88: 264: 51.72		PSD11_DROME (21-435): 1.22e-90: 282: 12.41
+	Hs
		121936 PSA2_HUMAN (3-236): 1.56e-45: 154: 38.14		PSD12_HUMAN (7-443): 3.17e-131: 387: 40.45
+	Sc
		771394 PSA4_YEAST (1-254): 1.72e-97: 287: 100.00		RPN6_YEAST (8-434): 2.76e-73: 238: 10.58
+	Hs
		121684 PSA2_HUMAN (3-236): 1.56e-45: 154: 38.14		PSD11_HUMAN (20-435): 2.54e-93: 289: 12.68
+	Dm
		771297 PSA2_DROME (4-214): 9.25e-44: 149: 40.28		PSD11_DROME (21-435): 1.22e-90: 282: 12.41
+	Dm
		771304 PSA2_DROME (4-214): 9.25e-44: 149: 40.28		CSN4_DROME (68-437): 2.53e-86: 271: 19.27
+	Sp
		293717 PSA2_SCHPO (4-236): 5.42e-40: 140: 39.11		RPN6_SCHPO (25-432): 2.33e-86: 272: 12.95