Interactor 1: VHL (P40337)
von Hippel-Lindau disease tumor suppressor (Protein G7) (pVHL)
Gene: VHL
Interactor 2: CUL2 (Q13617)
Cullin-2 (CUL-2)
Gene: CUL2
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.99 | 1.00 | 0.996 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 31444342, 11384984, 33961781, 19030229, 15966899, 21145461, 9122164, 10449727, 15601820, 18323857, 25661653, 26735018, 26751167, 26846855, 26743088, 27697924, 28514442, 28775317, 17353931, 18523483 and 33 others
more... |
| Identification Methods | pull down, affinity chromatography technology, two hybrid, biochemical, anti tag coimmunoprecipitation, tandem affinity purification, anti bait coimmunoprecipitation |
| Interaction Type | direct interaction, physical association, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | Cullin~VHL_C |
| Common GO terms | GO:0004842 - ubiquitin-protein transferase activity GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0016567 - protein ubiquitination GO:0030891 - VCB complex |
| Homologous interactions | 3 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
