HitPredict

Interactor 1: VHL (P40337)
von Hippel-Lindau disease tumor suppressor (Protein G7) (pVHL)
Gene: VHL

Interactor 2: NACC2 (Q96BF6)
Nucleus accumbens-associated protein 2 (NAC-2) (BTB/POZ domain-containing protein 14A) (Repressor with BTB domain and BEN domain)
Gene: NACC2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	32814053
Identification Methods	two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005739 - mitochondrion GO:0008285 - negative regulation of cell population proliferation
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 213 Hs			1 587
+	Hs
		771848 VHL_HUMAN (1-213): 3.45e-146: 407: 100.00		ZN131_HUMAN (8-371): 5.56e-61: 214: 18.21
+	Hs
		771985 VHL_HUMAN (1-213): 3.45e-146: 407: 100.00		ZBTB6_HUMAN (2-409): 1.7e-58: 203: 17.25
+	Hs
		771999 VHL_HUMAN (1-213): 3.45e-146: 407: 100.00		KLH12_HUMAN (10-326): 2.89e-53: 192: 12.92
+	Hs
		772028 VHL_HUMAN (1-213): 3.45e-146: 407: 100.00		ZBT49_HUMAN (12-323): 1.6e-45: 173: 24.21
+	Hs
		771940 VHL_HUMAN (1-213): 3.45e-146: 407: 100.00		ZBT17_HUMAN (109-459): 4.09e-41: 161: 9.58
+	Hs
		157184 VHL_HUMAN (1-213): 3.45e-146: 407: 100.00		BACH1_HUMAN (3-132): 2.13e-35: 143: 32.33