Interactor 1: VHL (P40337)
von Hippel-Lindau disease tumor suppressor (Protein G7) (pVHL)
Gene: VHL
Interactor 2: EPAS1 (Q99814)
Endothelial PAS domain-containing protein 1 (EPAS-1) (Basic-helix-loop-helix-PAS protein MOP2) (Class E basic helix-loop-helix protein 73) (bHLHe73) (HIF-1-alpha-like factor) (HLF) (Hypoxia-inducible factor 2-alpha) (HIF-2-alpha) (HIF2-alpha) (Member of PAS protein 2) (PAS domain-containing protein 2)
Gene: EPAS1
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.97 | 1.00 | 0.987 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 26342197, 26735578, 10878807, 10353251, 25500545, 28775317, 24981860, 33591636, 17967880, 36175619, 12604794, 11331613, 10823831, 11292862, 15611064, 17339318, 21685897, 17986458, 23401859, 30487161 |
| Identification Methods | affinity chromatography technology, pull down, two hybrid, gal4 vp16 complementation, tandem affinity purification, far western blotting |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | HIF-1~VHL |
| Common GO terms | GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0071456 - cellular response to hypoxia |
| Homologous interactions | 8 |
Homologous interactions
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
