HitPredict

Interactor 1: YTA12 (P40341)
Mitochondrial inner membrane m-AAA protease component YTA12 (EC 3.4.24.-) (EC 3.6.-.-) (Tat-binding homolog 12)
Gene: YTA12

Interactor 2: PHB2 (P50085)
Prohibitin-2
Gene: PHB2

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	16429126, 37968396
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0005743 - mitochondrial inner membrane
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 825 Sc			1 310
+	Sc
		772369 YTA12_YEAST (1-825): 0: 723: 100.00		PHB1_YEAST (37-293): 1.61e-85: 260: 55.04
+	Hs
		1305325 AFG32_HUMAN (121-816): 0: 571: 47.80		PHB2_HUMAN (22-309): 1.28e-98: 293: 51.72
+	Hs
		719266 AFG32_HUMAN (121-816): 0: 571: 47.80		PHB1_HUMAN (39-297): 2.95e-89: 269: 50.00
+	Sc
		764776 AFG3_YEAST (117-810): 2.64e-177: 530: 54.94		PHB2_YEAST (1-310): 7.61e-100: 297: 100.00
+	At
		1258446 FTSHA_ARATH (137-791): 1.13e-180: 541: 47.00		PHB2_ARATH (27-289): 1.03e-90: 273: 54.75
+	At
		1258445 FTSHA_ARATH (137-791): 1.13e-180: 541: 47.00		PHB6_ARATH (27-289): 2.09e-90: 272: 52.85
+	At
		138214 FTSHA_ARATH (137-791): 1.13e-180: 541: 47.00		PHB3_ARATH (28-297): 2.36e-88: 267: 50.55
+	At
		221625 FTSHA_ARATH (137-791): 1.13e-180: 541: 47.00		PHB1_ARATH (26-289): 4.68e-88: 266: 53.18
+	Sc
		764773 AFG3_YEAST (117-810): 2.64e-177: 530: 54.94		PHB1_YEAST (37-293): 1.61e-85: 260: 55.04
+	Hs
		1303088 YMEL1_HUMAN (208-791): 3.45e-142: 440: 32.32		PHB2_HUMAN (22-309): 1.28e-98: 293: 51.72
+	Hs
		875252 TERA_HUMAN (63-611): 2.15e-86: 293: 20.43		PHB2_HUMAN (22-309): 1.28e-98: 293: 51.72
+	Hs
		718657 TERA_HUMAN (63-611): 2.15e-86: 293: 20.43		PHB1_HUMAN (39-297): 2.95e-89: 269: 50.00