HitPredict

Interactor 1: PBX3 (P40426)
Pre-B-cell leukemia transcription factor 3 (Homeobox protein PBX3)
Gene: PBX3

Interactor 2: PKNX2 (Q96KN3)
Homeobox protein PKNOX2 (Homeobox protein PREP-2) (PBX/knotted homeobox 2)
Gene: PKNOX2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Homeobox_KN~Homeobox_KN
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 434 Hs			1 472
+	Mm
		192614 PBX3_MOUSE (1-434): 2.14e-153: 443: 99.77		PKNX2_MOUSE (1-472): 6.52e-130: 386: 97.89
+	Hs
		773086 PBX1_HUMAN (1-434): 1.05e-136: 400: 81.84		PKNX2_HUMAN (1-472): 4.99e-131: 389: 100.00
+	Mm
		784127 PBX1_MOUSE (1-434): 1.05e-136: 400: 81.84		PKNX2_MOUSE (1-472): 6.52e-130: 386: 97.89
+	Mm
		192611 PBX3_MOUSE (1-434): 2.14e-153: 443: 99.77		MEIS2_MOUSE (1-464): 7.49e-103: 317: 29.50
+	Hs
		154471 PBX3_HUMAN (1-434): 1.13e-153: 444: 100.00		MEIS2_HUMAN (1-464): 2.27e-102: 315: 29.50
+	Mm
		192613 PBX3_MOUSE (1-434): 2.14e-153: 443: 99.77		MEIS1_MOUSE (1-383): 1.06e-102: 314: 35.10
+	Mm
		192601 PBX3_MOUSE (1-434): 2.14e-153: 443: 99.77		PKNX1_MOUSE (13-472): 1.43e-96: 299: 56.90
+	Hs
		773157 PBX3_HUMAN (1-434): 1.13e-153: 444: 100.00		PKNX1_HUMAN (13-472): 1.03e-94: 295: 56.48
+	Mm
		193673 PBX2_MOUSE (43-434): 7.17e-118: 352: 79.44		PKNX2_MOUSE (1-472): 6.52e-130: 386: 97.89
+	Mm
		784122 PBX1_MOUSE (1-434): 1.05e-136: 400: 81.84		MEIS2_MOUSE (1-464): 7.49e-103: 317: 29.50
+	Hs
		154469 PBX1_HUMAN (1-434): 1.05e-136: 400: 81.84		MEIS2_HUMAN (1-464): 2.27e-102: 315: 29.50
+	Hs
		129969 PBX1_HUMAN (1-434): 1.05e-136: 400: 81.84		MEIS1_HUMAN (1-383): 9.92e-103: 314: 35.10
+	Mm
		784125 PBX1_MOUSE (1-434): 1.05e-136: 400: 81.84		MEIS1_MOUSE (1-383): 1.06e-102: 314: 35.10
+	Mm
		250966 PBX1_MOUSE (1-434): 1.05e-136: 400: 81.84		PKNX1_MOUSE (13-472): 1.43e-96: 299: 56.90
+	Hs
		773061 PBX1_HUMAN (1-434): 1.05e-136: 400: 81.84		PKNX1_HUMAN (13-472): 1.03e-94: 295: 56.48
+	Mm
		193670 PBX2_MOUSE (43-434): 7.17e-118: 352: 79.44		MEIS2_MOUSE (1-464): 7.49e-103: 317: 29.50
+	Mm
		193671 PBX2_MOUSE (43-434): 7.17e-118: 352: 79.44		MEIS1_MOUSE (1-383): 1.06e-102: 314: 35.10
+	Mm
		193667 PBX2_MOUSE (43-434): 7.17e-118: 352: 79.44		PKNX1_MOUSE (13-472): 1.43e-96: 299: 56.90
+	Hs
		773153 PBX3_HUMAN (1-434): 1.13e-153: 444: 100.00		PBX3_HUMAN (260-470): 7.25e-48: 172: 21.68
+	Hs
		773054 PBX1_HUMAN (1-434): 1.05e-136: 400: 81.84		PBX2_HUMAN (238-470): 3.71e-49: 175: 20.25