HitPredict

Interactor 1: NU159 (P40477)
Nucleoporin NUP159 (Nuclear pore protein NUP159)
Gene: NUP159

Interactor 2: IMB1 (Q06142)
Importin subunit beta-1 (Importin-95) (Karyopherin subunit beta-1) (Karyopherin-95)
Gene: KAP95

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	9412460, 9412461, 15557115, 17418788
Identification Methods	affinity chromatography technology, pull down, far western blotting
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005635 - nuclear envelope GO:0005643 - nuclear pore GO:0006607 - NLS-bearing protein import into nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1460 Sc			1 861
+	Sc
		687954 NU159_YEAST (1-1460): 0: 586: 100.00		IMB3_YEAST (7-813): 1.96e-115: 379: 16.43
+	Sc
		767656 NU159_YEAST (1-1460): 0: 586: 100.00		IMB4_YEAST (5-756): 1.06e-49: 192: 14.36
+	Sc
		541927 NSP1_YEAST (404-1068): 4.68e-16: 86.1: 19.91		IMB1_YEAST (1-861): 3.78e-177: 534: 100.00
+	Hs
		857978 NUP98_HUMAN (569-1203): 3.25e-23: 109: 13.08		IMB1_HUMAN (4-857): 7.07e-167: 509: 32.96
+	Sc
		830681 NU145_YEAST (380-734): 1.66e-13: 77.9: 14.40		IMB1_YEAST (1-861): 3.78e-177: 534: 100.00
+	Sc
		971878 NU100_YEAST (414-1004): 1.29e-12: 74.9: 16.82		IMB1_YEAST (1-861): 3.78e-177: 534: 100.00
+	Hs
		72728 B4DET5_HUMAN (389-1160): 4.01e-12: 73.4: 10.39		IMB1_HUMAN (4-857): 7.07e-167: 509: 32.96
+	Hs
		1060869 P121A_HUMAN (412-889): 8.39e-12: 72.2: 16.51		IMB1_HUMAN (4-857): 7.07e-167: 509: 32.96
+	Hs
		858024 NUP98_HUMAN (569-1203): 3.25e-23: 109: 13.08		TNPO1_HUMAN (12-807): 1.04e-126: 404: 15.37
+	Hs
		155553 NUP98_HUMAN (569-1203): 3.25e-23: 109: 13.08		TNPO2_HUMAN (15-807): 3.1e-120: 387: 15.44
+	Sc
		541851 NSP1_YEAST (404-1068): 4.68e-16: 86.1: 19.91		IMB3_YEAST (7-813): 1.96e-115: 379: 16.43
+	Sc
		687969 NU145_YEAST (380-734): 1.66e-13: 77.9: 14.40		IMB3_YEAST (7-813): 1.96e-115: 379: 16.43
+	Sc
		687986 NU100_YEAST (414-1004): 1.29e-12: 74.9: 16.82		IMB3_YEAST (7-813): 1.96e-115: 379: 16.43
+	Hs
		178151 IF4G1_HUMAN (430-973): 2.4e-15: 84.2: 12.81		IPO8_HUMAN (1-860): 1.24e-95: 324: 11.86
+	Ce
		136533 O01576_CAEEL (406-767): 1.9e-13: 77.6: 17.45		Q9N5V3_CAEEL (1-833): 3.22e-91: 313: 14.63
+	Sc
		541885 NSP1_YEAST (404-1068): 4.68e-16: 86.1: 19.91		IMB4_YEAST (5-756): 1.06e-49: 192: 14.36
+	Hs
		127176 MUC1_HUMAN (45-1069): 6.9e-54: 209: 8.98		IPO5_HUMAN (4-604): 5.13e-11: 68.8: 9.23
+	Sc
		767712 NU100_YEAST (414-1004): 1.29e-12: 74.9: 16.82		IMB4_YEAST (5-756): 1.06e-49: 192: 14.36
+	Hs
		236394 CO1A1_HUMAN (131-898): 4.65e-18: 93.1: 7.42		RNBP6_HUMAN (5-579): 1.11e-09: 64.6: 10.69
+	Hs
		127345 P121A_HUMAN (412-889): 8.39e-12: 72.2: 16.51		IPO5_HUMAN (4-604): 5.13e-11: 68.8: 9.23