HitPredict

Interactor 1: DPH1 (P40487)
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 (EC 2.5.1.108) (Diphthamide biosynthesis protein 1) (Diphtheria toxin resistance protein 1) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1)
Gene: DPH1

Interactor 2: DPH3 (Q3E840)
Diphthamide biosynthesis protein 3 (Kluyveromyces lactis toxin-insensitive protein 11)
Gene: KTI11

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.745

Property	Details
Experiments	25543256, 23645155, 23468660, 12940988, 16554755, 27694803, 18627462, 37968396
Identification Methods	anti tag coimmunoprecipitation, affinity chromatography technology, tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0017183 - protein histidyl modification to diphthamide GO:0090560 - 2-(3-amino-3-carboxypropyl)histidine synthase activity
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1 425 Sc			1 82
+	Sc
		690375 DPH2_YEAST (67-414): 6.67e-112: 340: 21.47		DPH3_YEAST (1-82): 1.18e-39: 127: 100.00
+	Hs
		1291628 DPH2_HUMAN (78-418): 3.92e-114: 344: 22.38		DPH3_HUMAN (3-64): 8.26e-29: 100: 48.39