HitPredict

Interactor 1: STAT3 (P40763)
Signal transducer and activator of transcription 3 (Acute-phase response factor)
Gene: STAT3

Interactor 2: STAT1 (P42224)
Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84)
Gene: STAT1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.978

The method score is based on:

Property Details
Experiments 25609649, 16007122, 11594781, 12070153, 35140242, 28514442, 11722592, 33961781, 15284024, 26966684, 31462771, 8662591
Identification Methods affinity chromatography technology, pull down, proximity labelling technology, anti tag coimmunoprecipitation, tandem affinity purification, competition binding
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains SH2~SH2, STAT_alpha~STAT_bind, STAT_alpha~STAT_int, STAT_bind~STAT_bind, STAT_int~STAT_int
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003700 - DNA-binding transcription factor activity
and 15 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

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1 750
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Last updated: 15 Jul 2024