HitPredict

Interactor 1: STAT3 (P40763)
Signal transducer and activator of transcription 3 (Acute-phase response factor)
Gene: STAT3

Interactor 2: MK08 (P45983)
Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (JNK-46) (Stress-activated protein kinase 1c) (SAPK1c) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1)
Gene: MAPK8

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	0.60	0.660

Property	Details
Experiments	12562765, 10521505, 15979846
Identification Methods	enzymatic study, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0010628 - positive regulation of gene expression and 1 others more... GO:0019903 - protein phosphatase binding
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 770 Hs			1 427
+	Hs
		776600 STAT3_HUMAN (1-770): 0: 1048: 100.00		MK09_HUMAN (1-427): 5.18e-163: 467: 80.80
+	Hs
		173854 STAT3_HUMAN (1-770): 0: 1048: 100.00		MK13_HUMAN (6-373): 1.37e-129: 380: 45.14
+	Mm
		786542 STAT3_MOUSE (1-770): 0: 1049: 99.87		MK03_MOUSE (20-370): 9.11e-84: 263: 40.56
+	Hs
		658824 STAT3_HUMAN (1-770): 0: 1048: 100.00		MK01_HUMAN (20-359): 2.94e-84: 263: 42.98
+	Hs
		647492 STAT3_HUMAN (1-770): 0: 1048: 100.00		MK03_HUMAN (20-359): 5.22e-83: 261: 41.26
+	Hs
		658828 STAT1_HUMAN (1-749): 0: 929: 51.52		MK01_HUMAN (20-359): 2.94e-84: 263: 42.98
+	Mm
		926434 Q99K94_MOUSE (1-715): 0: 909: 53.62		MK01_MOUSE (20-359): 2.95e-84: 263: 42.98
+	Hs
		658829 STA5A_HUMAN (1-734): 0: 745: 30.42		MK01_HUMAN (20-359): 2.94e-84: 263: 42.98