HitPredict

Interactor 1: STAT3 (P40763)
Signal transducer and activator of transcription 3 (Acute-phase response factor)
Gene: STAT3

Interactor 2: BLK (P51451)
Tyrosine-protein kinase Blk (EC 2.7.10.2) (B lymphocyte kinase) (p55-Blk)
Gene: BLK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.925

Property	Details
Experiments	25416956, 32296183, 31515488, 29892012, unassigned1304
Identification Methods	two hybrid, validated two hybrid, two hybrid array, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1
Common GO terms	GO:0005102 - signaling receptor binding GO:0005829 - cytosol GO:0030154 - cell differentiation
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 770 Hs			1 505
+	Hs
		442788 STAT3_HUMAN (1-770): 0: 1048: 100.00		HCK_HUMAN (1-505): 0: 574: 62.92
+	Hs
		411624 STAT3_HUMAN (1-770): 0: 1048: 100.00		LCK_HUMAN (1-505): 0: 569: 59.15
+	Hs
		412065 STAT3_HUMAN (1-770): 0: 1048: 100.00		FYN_HUMAN (1-503): 0: 562: 54.75
+	Hs
		522829 STAT3_HUMAN (1-770): 0: 1048: 100.00		SRC_HUMAN (1-503): 0: 560: 54.22
+	Mm
		403422 STAT3_MOUSE (1-770): 0: 1049: 99.87		SRC_MOUSE (1-503): 0: 557: 54.51
+	Hs
		433628 STAT3_HUMAN (1-770): 0: 1048: 100.00		LYN_HUMAN (1-505): 0: 551: 59.77
+	Hs
		454804 STAT3_HUMAN (1-770): 0: 1048: 100.00		FGR_HUMAN (1-503): 0: 550: 53.61
+	Hs
		776597 STAT3_HUMAN (1-770): 0: 1048: 100.00		ABL2_HUMAN (8-503): 2.23e-165: 500: 38.67
+	Mm
		729741 STAT3_MOUSE (1-770): 0: 1049: 99.87		BTK_MOUSE (4-498): 1.45e-157: 464: 33.73
+	Hs
		776660 STAT3_HUMAN (1-770): 0: 1048: 100.00		BTK_HUMAN (4-498): 2.89e-156: 461: 34.12
+	Hs
		522836 STAT1_HUMAN (1-749): 0: 929: 51.52		SRC_HUMAN (1-503): 0: 560: 54.22
+	Hs
		337403 STA5B_HUMAN (1-734): 0: 752: 30.55		ABL1_HUMAN (54-504): 6.77e-163: 492: 41.09
+	Hs
		337381 STA5A_HUMAN (1-734): 0: 745: 30.42		ABL1_HUMAN (54-504): 6.77e-163: 492: 41.09
+	Hs
		849890 STA5B_HUMAN (1-734): 0: 752: 30.55		PTK6_HUMAN (60-493): 7.36e-158: 458: 40.68
+	Hs
		786602 STA5A_HUMAN (1-734): 0: 745: 30.42		BTK_HUMAN (4-498): 2.89e-156: 461: 34.12