HitPredict

Interactor 1: STAT3 (P40763)
Signal transducer and activator of transcription 3 (Acute-phase response factor)
Gene: STAT3

Interactor 2: ROR1 (Q01973)
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (Neurotrophic tyrosine kinase, receptor-related 1)
Gene: ROR1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	25733697
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0016310 - phosphorylation GO:0051092 - positive regulation of NF-kappaB transcription factor activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 770 Hs			1 937
+	Hs
		609197 STAT3_HUMAN (1-770): 0: 1048: 100.00		FGFR3_HUMAN (12-806): 3.86e-160: 491: 19.69
+	Hs
		572592 STAT3_HUMAN (1-770): 0: 1048: 100.00		VGFR1_HUMAN (33-898): 3.59e-153: 488: 18.07
+	Hs
		507894 STAT3_HUMAN (1-770): 0: 1048: 100.00		FGFR1_HUMAN (19-798): 2.01e-155: 480: 17.93
+	Hs
		729621 STAT3_HUMAN (1-770): 0: 1048: 100.00		VGFR2_HUMAN (38-911): 4.89e-150: 480: 16.41
+	Hs
		434150 STAT3_HUMAN (1-770): 0: 1048: 100.00		RET_HUMAN (170-849): 1.43e-143: 457: 22.46
+	Hs
		572594 STAT1_HUMAN (1-749): 0: 929: 51.52		VGFR1_HUMAN (33-898): 3.59e-153: 488: 18.07
+	Hs
		729622 STAT1_HUMAN (1-749): 0: 929: 51.52		VGFR2_HUMAN (38-911): 4.89e-150: 480: 16.41
+	Hs
		384414 STAT3_HUMAN (1-770): 0: 1048: 100.00		NTRK1_HUMAN (478-748): 5.71e-72: 255: 46.89
+	Hs
		776663 STAT3_HUMAN (1-770): 0: 1048: 100.00		DDR1_HUMAN (467-743): 7.05e-56: 211: 37.79
+	Mm
		786520 STAT3_MOUSE (1-770): 0: 1049: 99.87		FER_MOUSE (461-746): 2.53e-55: 208: 39.02
+	Hs
		435568 STAT3_HUMAN (1-770): 0: 1048: 100.00		IGF1R_HUMAN (467-742): 3.41e-54: 207: 39.71
+	Hs
		776856 STAT3_HUMAN (1-770): 0: 1048: 100.00		ALK_HUMAN (404-746): 1.74e-53: 205: 35.20
+	Hs
		849893 STA5B_HUMAN (1-734): 0: 752: 30.55		ERBB4_HUMAN (113-932): 1.7e-142: 458: 18.75
+	Hs
		384428 STAT1_HUMAN (1-749): 0: 929: 51.52		NTRK1_HUMAN (478-748): 5.71e-72: 255: 46.89
+	Hs
		601474 STAT3_HUMAN (1-770): 0: 1048: 100.00		FGFR2_HUMAN (22-182): 1.27e-18: 93.3: 19.02
+	Hs
		786329 STAT1_HUMAN (1-749): 0: 929: 51.52		DDR1_HUMAN (467-743): 7.05e-56: 211: 37.79
+	Hs
		384522 STA5B_HUMAN (1-734): 0: 752: 30.55		NTRK1_HUMAN (478-748): 5.71e-72: 255: 46.89
+	Hs
		849885 STA5B_HUMAN (1-734): 0: 752: 30.55		DDR1_HUMAN (467-743): 7.05e-56: 211: 37.79
+	Hs
		601481 STA5B_HUMAN (1-734): 0: 752: 30.55		FGFR2_HUMAN (22-182): 1.27e-18: 93.3: 19.02
+	Hs
		601477 STA5A_HUMAN (1-734): 0: 745: 30.42		FGFR2_HUMAN (22-182): 1.27e-18: 93.3: 19.02