HitPredict - High confidence protein-protein interactions

Interactor 1: STAT3 (P40763)
Signal transducer and activator of transcription 3 (Acute-phase response factor)
Gene: STAT3

Interactor 2: HIF1A (Q16665)
Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8)
Gene: HIF1A

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.683

Property	Details
Experiments	23991099, 23604114, 18985005, 15735682
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific GO:0003700 - DNA-binding transcription factor activity and 19 others more... GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006355 - regulation of DNA-templated transcription GO:0006357 - regulation of transcription by RNA polymerase II GO:0007165 - signal transduction GO:0010575 - positive regulation of vascular endothelial growth factor production GO:0010628 - positive regulation of gene expression GO:0010629 - negative regulation of gene expression GO:0019901 - protein kinase binding GO:0045648 - positive regulation of erythrocyte differentiation GO:0045766 - positive regulation of angiogenesis GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0061629 - RNA polymerase II-specific DNA-binding transcription factor binding GO:0090575 - RNA polymerase II transcription regulator complex GO:1900017 - positive regulation of cytokine production involved in inflammatory response GO:1902895 - positive regulation of miRNA transcription
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1	770
Hs

1	826

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Last updated: 15 Jul 2024