HitPredict

Interactor 1: STAT3 (P40763)
Signal transducer and activator of transcription 3 (Acute-phase response factor)
Gene: STAT3

Interactor 2: UBP28 (Q96RU2)
Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.4.19.12) (Deubiquitinating enzyme 28) (Ubiquitin thioesterase 28) (Ubiquitin-specific-processing protease 28)
Gene: USP28

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	30881015, 36442624
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0008283 - cell population proliferation
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 770 Hs			1 1077
+	Hs
		786404 STAT1_HUMAN (1-749): 0: 929: 51.52		UBP13_HUMAN (28-649): 3.31e-72: 259: 12.85
+	Mm
		786532 STAT3_MOUSE (1-770): 0: 1049: 99.87		UBP22_MOUSE (428-654): 3.68e-11: 69.2: 18.42
+	Hs
		776858 STAT3_HUMAN (1-770): 0: 1048: 100.00		UBP22_HUMAN (428-654): 3.12e-11: 69.2: 18.42
+	Hs
		271048 STAT1_HUMAN (1-749): 0: 929: 51.52		UBP2_HUMAN (434-653): 1.59e-15: 83.1: 17.86
+	Hs
		786450 STAT1_HUMAN (1-749): 0: 929: 51.52		UBP22_HUMAN (428-654): 3.12e-11: 69.2: 18.42
+	Mm
		1125412 Q99K94_MOUSE (1-715): 0: 909: 53.62		UBP22_MOUSE (428-654): 3.68e-11: 69.2: 18.42
+	Hs
		271058 STA5B_HUMAN (1-734): 0: 752: 30.55		UBP2_HUMAN (434-653): 1.59e-15: 83.1: 17.86