HitPredict

Interactor 1: STAT3 (P40763)
Signal transducer and activator of transcription 3 (Acute-phase response factor)
Gene: STAT3

Interactor 2: SH22A (Q9NP31)
SH2 domain-containing protein 2A (SH2 domain-containing adapter protein) (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein)
Gene: SH2D2A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.767

Property	Details
Experiments	25814554, unassigned1126
Identification Methods	two hybrid, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SH2~SH2
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction GO:0030154 - cell differentiation
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 770 Hs			1 389
+	Mm
		403422 STAT3_MOUSE (1-770): 0: 1049: 99.87		SRC_MOUSE (4-280): 1.66e-51: 182: 17.73
+	Hs
		454804 STAT3_HUMAN (1-770): 0: 1048: 100.00		FGR_HUMAN (6-258): 5.75e-49: 175: 15.64
+	Hs
		522829 STAT3_HUMAN (1-770): 0: 1048: 100.00		SRC_HUMAN (21-280): 1.14e-48: 174: 17.73
+	Hs
		433628 STAT3_HUMAN (1-770): 0: 1048: 100.00		LYN_HUMAN (9-313): 7.12e-48: 171: 14.82
+	Hs
		776638 STAT3_HUMAN (1-770): 0: 1048: 100.00		GRB2_HUMAN (56-256): 4.42e-50: 169: 15.71
+	Hs
		412065 STAT3_HUMAN (1-770): 0: 1048: 100.00		FYN_HUMAN (38-280): 1.65e-45: 165: 15.67
+	Hs
		442788 STAT3_HUMAN (1-770): 0: 1048: 100.00		HCK_HUMAN (6-212): 2.97e-45: 165: 15.93
+	Hs
		411624 STAT3_HUMAN (1-770): 0: 1048: 100.00		LCK_HUMAN (22-210): 4.42e-45: 164: 17.31
+	Mm
		786511 STAT3_MOUSE (1-770): 0: 1049: 99.87		KSYK_MOUSE (95-213): 1.04e-17: 86.9: 25.60
+	Hs
		776598 STAT3_HUMAN (1-770): 0: 1048: 100.00		KSYK_HUMAN (94-213): 1.09e-17: 86.9: 23.81
+	Hs
		522836 STAT1_HUMAN (1-749): 0: 929: 51.52		SRC_HUMAN (21-280): 1.14e-48: 174: 17.73
+	Hs
		802601 STAT4_HUMAN (1-729): 0: 893: 48.44		CRK_HUMAN (95-341): 6.51e-46: 161: 17.28
+	Mm
		786459 STAT1_MOUSE (1-749): 0: 914: 51.32		ZAP70_MOUSE (94-193): 6.76e-15: 78.3: 24.53
+	Hs
		802809 STA5B_HUMAN (1-734): 0: 752: 30.55		CRKL_HUMAN (95-347): 5.6e-49: 169: 21.76
+	Hs
		786590 STA5A_HUMAN (1-734): 0: 745: 30.42		CRKL_HUMAN (95-347): 5.6e-49: 169: 21.76
+	Hs
		849890 STA5B_HUMAN (1-734): 0: 752: 30.55		PTK6_HUMAN (84-194): 4.58e-32: 127: 28.93