HitPredict

Interactor 1: STAT3 (P40763)
Signal transducer and activator of transcription 3 (Acute-phase response factor)
Gene: STAT3

Interactor 2: I20RA (Q9UHF4)
Interleukin-20 receptor subunit alpha (IL-20 receptor subunit alpha) (IL-20R-alpha) (IL-20RA) (Cytokine receptor class-II member 8) (Cytokine receptor family 2 member 8) (CRF2-8) (IL-20R1) (ZcytoR7)
Gene: IL20RA

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0019221 - cytokine-mediated signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 770 Hs			1 553
+	Mm
		786535 STAT3_MOUSE (1-770): 0: 1049: 99.87		I10R1_MOUSE (17-547): 1.23e-139: 417: 19.93
+	Hs
		776745 STAT3_HUMAN (1-770): 0: 1048: 100.00		I22R1_HUMAN (17-535): 6.36e-94: 300: 19.19
+	Mm
		546497 STAT3_MOUSE (1-770): 0: 1049: 99.87		INGR1_MOUSE (17-452): 4.43e-85: 273: 16.09
+	Mm
		786560 STAT3_MOUSE (1-770): 0: 1049: 99.87		INLR1_MOUSE (10-513): 5.4e-78: 257: 16.15
+	Hs
		786269 STAT1_HUMAN (1-749): 0: 929: 51.52		INAR2_HUMAN (13-487): 2.03e-100: 315: 14.54
+	Mm
		193268 STAT1_MOUSE (1-749): 0: 914: 51.32		INAR2_MOUSE (18-487): 1.53e-102: 320: 17.51
+	Hs
		566010 STAT3_HUMAN (1-770): 0: 1048: 100.00		INAR1_HUMAN (20-361): 6.82e-50: 182: 19.44
+	Hs
		546441 STAT1_HUMAN (1-749): 0: 929: 51.52		INGR1_HUMAN (12-452): 6.71e-88: 281: 16.52
+	Mm
		546502 Q99K94_MOUSE (1-715): 0: 909: 53.62		INGR1_MOUSE (17-452): 4.43e-85: 273: 16.09
+	Hs
		701706 STAT3_HUMAN (1-770): 0: 1048: 100.00		IL3RB_HUMAN (10-534): 1.51e-25: 113: 12.15
+	Hs
		500951 STAT3_HUMAN (1-770): 0: 1048: 100.00		GHR_HUMAN (20-455): 5.45e-12: 70.5: 11.47
+	Hs
		566011 STAT1_HUMAN (1-749): 0: 929: 51.52		INAR1_HUMAN (20-361): 6.82e-50: 182: 19.44
+	Hs
		819579 STAT2_HUMAN (1-728): 0: 786: 38.47		INAR2_HUMAN (13-487): 2.03e-100: 315: 14.54
+	Mm
		708082 STAT1_MOUSE (1-749): 0: 914: 51.32		INAR1_MOUSE (23-401): 3.8e-42: 161: 17.77
+	Mm
		786650 STA5A_MOUSE (1-734): 0: 757: 30.46		PRLR_MOUSE (17-443): 1.47e-70: 239: 13.53
+	Hs
		566017 STAT2_HUMAN (1-728): 0: 786: 38.47		INAR1_HUMAN (20-361): 6.82e-50: 182: 19.44
+	Hs
		560469 STA5B_HUMAN (1-734): 0: 752: 30.55		PRLR_HUMAN (35-536): 3.47e-45: 170: 13.31
+	Hs
		701707 STA5A_HUMAN (1-734): 0: 745: 30.42		IL3RB_HUMAN (10-534): 1.51e-25: 113: 12.15
+	Hs
		500954 STA5B_HUMAN (1-734): 0: 752: 30.55		GHR_HUMAN (20-455): 5.45e-12: 70.5: 11.47
+	Hs
		566012 STAT6_HUMAN (1-753): 0: 627: 24.10		INAR1_HUMAN (20-361): 6.82e-50: 182: 19.44