HitPredict

Interactor 1: RAC1 (P40792)
Ras-related protein Rac1
Gene: RAC1

Interactor 2: SPRI (Q8MQW8)
Protein sprint (SH2 poly-proline-containing Ras-interactor protein)
Gene: SPRI

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	15710747
Identification Methods	two hybrid, two hybrid fragment pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	RA~Ras, Ras~VPS9
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction GO:0019901 - protein kinase binding GO:0048675 - axon extension GO:1903688 - positive regulation of border follicle cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Dm			1 1789
+	Dm
		819744 RAC2_DROME (1-192): 3.83e-79: 235: 93.23		SPRI_DROME (1-1789): 0: 1399: 100.00
+	Ce
		104435 RAC1_CAEEL (1-192): 1.09e-81: 242: 80.73		G5EBS9_CAEEL (967-1786): 4.8e-170: 543: 22.87
+	Hs
		412123 RAC1_HUMAN (1-192): 2.19e-83: 246: 91.67		FYN_HUMAN (317-630): 1.18e-53: 199: 14.78
+	Hs
		522888 RAC1_HUMAN (1-192): 2.19e-83: 246: 91.67		SRC_HUMAN (330-579): 1.03e-53: 199: 16.54
+	Hs
		411980 RAC2_HUMAN (1-192): 5.01e-80: 238: 89.06		FYN_HUMAN (317-630): 1.18e-53: 199: 14.78
+	Hs
		412113 CDC42_HUMAN (1-192): 7.64e-77: 229: 69.27		FYN_HUMAN (317-630): 1.18e-53: 199: 14.78
+	Hs
		433314 RAC1_HUMAN (1-192): 2.19e-83: 246: 91.67		YES_HUMAN (336-579): 7.94e-47: 179: 14.68
+	Hs
		433475 RHOJ_HUMAN (2-190): 4.27e-80: 239: 60.32		YES_HUMAN (336-579): 7.94e-47: 179: 14.68
+	Hs
		433239 RAC2_HUMAN (1-192): 5.01e-80: 238: 89.06		YES_HUMAN (336-579): 7.94e-47: 179: 14.68
+	Hs
		433322 RHOG_HUMAN (1-192): 2.98e-77: 230: 67.19		YES_HUMAN (336-579): 7.94e-47: 179: 14.68
+	Hs
		433305 CDC42_HUMAN (1-192): 7.64e-77: 229: 69.27		YES_HUMAN (336-579): 7.94e-47: 179: 14.68
+	Hs
		925353 RAC1_HUMAN (1-192): 2.19e-83: 246: 91.67		TENS3_HUMAN (453-605): 1.02e-32: 141: 20.33
+	Hs
		545440 RAC2_HUMAN (1-192): 5.01e-80: 238: 89.06		TENS3_HUMAN (453-605): 1.02e-32: 141: 20.33
+	Hs
		297823 RAC1_HUMAN (1-192): 2.19e-83: 246: 91.67		K0754_HUMAN (560-1147): 7.49e-25: 116: 15.24
+	Hs
		297840 RHOJ_HUMAN (2-190): 4.27e-80: 239: 60.32		K0754_HUMAN (560-1147): 7.49e-25: 116: 15.24
+	Hs
		297812 RAC2_HUMAN (1-192): 5.01e-80: 238: 89.06		K0754_HUMAN (560-1147): 7.49e-25: 116: 15.24
+	Ce
		105104 RAC1_CAEEL (1-192): 1.09e-81: 242: 80.73		G5ECF0_CAEEL (333-646): 5.58e-23: 109: 22.74
+	Hs
		297827 RHOG_HUMAN (1-192): 2.98e-77: 230: 67.19		K0754_HUMAN (560-1147): 7.49e-25: 116: 15.24
+	Hs
		297819 RAC3_HUMAN (1-191): 1.08e-76: 229: 89.53		K0754_HUMAN (560-1147): 7.49e-25: 116: 15.24
+	Hs
		73275 B4E1U9_HUMAN (1-192): 1.14e-88: 261: 56.12		RIN3_HUMAN (761-1089): 6.26e-09: 63.2: 10.30