HitPredict

Interactor 1: UBP8 (P40818)
Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8)
Gene: USP8

Interactor 2: CHM1B (Q7LBR1)
Charged multivesicular body protein 1b (CHMP1.5) (Chromatin-modifying protein 1b) (CHMP1b) (Vacuolar protein sorting-associated protein 46-2) (Vps46-2) (hVps46-2)
Gene: CHMP1B

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.687

Property	Details
Experiments	35995394, 17711858, 19302785
Identification Methods	fluorescent resonance energy transfer, affinity chromatography technology, two hybrid, pull down, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0010008 - endosome membrane GO:0030496 - midbody
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1118 Hs			1 199
+	Hs
		208820 UBP8_HUMAN (1-1118): 0: 830: 100.00		CHM2A_HUMAN (4-180): 3.37e-38: 132: 28.25
+	Hs
		777088 UBP8_HUMAN (1-1118): 0: 830: 100.00		CHMP3_HUMAN (4-183): 9.18e-38: 131: 16.11
+	Hs
		777087 UBP8_HUMAN (1-1118): 0: 830: 100.00		CHM2B_HUMAN (4-195): 2.49e-37: 130: 18.78
+	Hs
		777081 UBP8_HUMAN (1-1118): 0: 830: 100.00		CHM1A_HUMAN (4-197): 2.33e-36: 127: 55.10
+	Hs
		777084 UBP8_HUMAN (1-1118): 0: 830: 100.00		CHMP5_HUMAN (15-186): 4.8e-26: 101: 15.82
+	Sc
		693621 UBP4_YEAST (535-1109): 1.21e-109: 366: 23.86		VPS24_YEAST (11-189): 2.09e-29: 110: 16.11
+	Hs
		208873 UBP15_HUMAN (964-1106): 1.96e-34: 145: 49.65		CHM2A_HUMAN (4-180): 3.37e-38: 132: 28.25
+	Hs
		1024429 UBP4_HUMAN (964-1106): 5.42e-33: 140: 44.06		CHMP5_HUMAN (15-186): 4.8e-26: 101: 15.82