HitPredict

Interactor 1: UBP8 (P40818)
Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8)
Gene: USP8

Interactor 2: STAM1 (Q92783)
Signal transducing adapter molecule 1 (STAM-1)
Gene: STAM

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

Property	Details
Experiments	20736164, 29604273, 10982817, 16520378
Identification Methods	affinity chromatography technology, pull down, protein complementation assay
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 1118 Hs			1 540
+	Hs
		277018 UBP8_HUMAN (1-1118): 0: 830: 100.00		STAM2_HUMAN (1-533): 8.53e-122: 369: 54.65
+	Mm
		292345 UBP8_MOUSE (1-1118): 0: 785: 81.04		STAM2_MOUSE (1-533): 3.7e-117: 357: 52.60
+	Hs
		275176 UBP8_HUMAN (1-1118): 0: 830: 100.00		GRAP2_HUMAN (213-264): 2.75e-14: 75.9: 57.69
+	Hs
		777028 UBP8_HUMAN (1-1118): 0: 830: 100.00		GRB2_HUMAN (215-265): 2.32e-13: 71.2: 54.90
+	Mm
		292688 UBP8_MOUSE (1-1118): 0: 785: 81.04		GRAP2_MOUSE (213-264): 1.05e-13: 73.9: 55.77
+	Mm
		1141140 UBP8_MOUSE (1-1118): 0: 785: 81.04		GRB2_MOUSE (215-265): 2.65e-13: 71.2: 54.90
+	Hs
		1270632 UBP15_HUMAN (964-1106): 1.96e-34: 145: 49.65		STAM1_HUMAN (1-518): 1.32e-126: 382: 100.00
+	Hs
		259274 UBP12_HUMAN (767-1110): 2.83e-106: 339: 27.70		GRB2_HUMAN (215-265): 2.32e-13: 71.2: 54.90
+	Dm
		1280443 Q9VDD8_DROME (9-660): 1.72e-64: 238: 20.63		HRS_DROME (7-145): 4.23e-40: 156: 31.43