HitPredict

Interactor 1: UBP8 (P40818)
Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8)
Gene: USP8

Interactor 2: UBP28 (Q96RU2)
Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.4.19.12) (Deubiquitinating enzyme 28) (Ubiquitin thioesterase 28) (Ubiquitin-specific-processing protease 28)
Gene: USP28

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	22626734
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UCH~UCH
Common GO terms	GO:0004843 - cysteine-type deubiquitinase activity GO:0005634 - nucleus GO:0005829 - cytosol GO:0016579 - protein deubiquitination GO:0031647 - regulation of protein stability
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1118 Hs			1 1077
+	Hs
		1174030 UBP51_HUMAN (728-1110): 1.45e-100: 336: 24.76		UBP28_HUMAN (1-1077): 0: 1069: 100.00
+	Hs
		1301529 UBP21_HUMAN (605-1111): 9.13e-98: 323: 26.08		UBP28_HUMAN (1-1077): 0: 1069: 100.00
+	Hs
		777086 UBP8_HUMAN (1-1118): 0: 830: 100.00		UBP22_HUMAN (428-654): 3.12e-11: 69.2: 18.42
+	Hs
		1200179 UBP21_HUMAN (605-1111): 9.13e-98: 323: 26.08		UBP48_HUMAN (145-399): 5.66e-73: 264: 26.52
+	Hs
		1174034 UBP22_HUMAN (744-1109): 3.1e-111: 358: 27.72		UBP51_HUMAN (158-414): 1.36e-62: 228: 18.77
+	Hs
		64210 UBP27_HUMAN (744-1109): 3.62e-106: 341: 26.80		UBP51_HUMAN (158-414): 1.36e-62: 228: 18.77
+	Hs
		259273 UBP46_HUMAN (767-1109): 5.5e-107: 341: 27.22		UBP12_HUMAN (157-475): 5.94e-65: 226: 17.10
+	Hs
		1174033 UBP21_HUMAN (605-1111): 9.13e-98: 323: 26.08		UBP51_HUMAN (158-414): 1.36e-62: 228: 18.77
+	Mm
		292020 UBP2_MOUSE (529-1111): 9.36e-117: 376: 27.43		UBP2_MOUSE (434-648): 4.59e-15: 81.9: 17.35
+	Sc
		693630 UBP4_YEAST (535-1109): 1.21e-109: 366: 23.86		UBP15_YEAST (453-811): 1.01e-15: 84.6: 11.77
+	Hs
		1273868 UBP44_HUMAN (700-1109): 8.86e-99: 331: 24.35		UBP7_HUMAN (547-839): 8.01e-23: 107: 20.13
+	Hs
		1273952 UBP21_HUMAN (605-1111): 9.13e-98: 323: 26.08		UBP7_HUMAN (547-839): 8.01e-23: 107: 20.13
+	Hs
		64224 UBP22_HUMAN (744-1109): 3.1e-111: 358: 27.72		UBP27_HUMAN (562-658): 1.93e-11: 69.6: 22.68
+	Hs
		1357755 UBP22_HUMAN (744-1109): 3.1e-111: 358: 27.72		UBP22_HUMAN (428-654): 3.12e-11: 69.2: 18.42
+	Hs
		1013375 U17LO_HUMAN (776-1111): 7.12e-97: 320: 27.89		U17L2_HUMAN (446-745): 3.74e-21: 100: 13.49
+	Hs
		271216 UBP21_HUMAN (605-1111): 9.13e-98: 323: 26.08		UBP2_HUMAN (434-653): 1.59e-15: 83.1: 17.86