HitPredict

Interactor 1: UBP8 (P40818)
Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8)
Gene: USP8

Interactor 2: CHM1A (Q9HD42)
Charged multivesicular body protein 1a (Chromatin-modifying protein 1a) (CHMP1a) (Vacuolar protein sorting-associated protein 46-1) (Vps46-1) (hVps46-1)
Gene: CHMP1A

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.629

Property	Details
Experiments	17711858, 19302785
Identification Methods	pull down, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005769 - early endosome GO:0005829 - cytosol GO:0030496 - midbody
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 1118 Hs			1 196
+	Hs
		777087 UBP8_HUMAN (1-1118): 0: 830: 100.00		CHM2B_HUMAN (1-194): 3.99e-39: 134: 17.26
+	Hs
		208820 UBP8_HUMAN (1-1118): 0: 830: 100.00		CHM2A_HUMAN (1-177): 4.66e-38: 132: 24.29
+	Hs
		777088 UBP8_HUMAN (1-1118): 0: 830: 100.00		CHMP3_HUMAN (1-196): 6.58e-38: 132: 13.04
+	Hs
		777050 UBP8_HUMAN (1-1118): 0: 830: 100.00		CHM1B_HUMAN (1-196): 7.53e-36: 125: 55.61
+	Hs
		777078 UBP8_HUMAN (1-1118): 0: 830: 100.00		CHM4B_HUMAN (2-191): 2.01e-15: 73.2: 17.68
+	Hs
		777063 UBP8_HUMAN (1-1118): 0: 830: 100.00		CHM4C_HUMAN (2-175): 1.96e-12: 65.5: 16.48
+	Sc
		693621 UBP4_YEAST (535-1109): 1.21e-109: 366: 23.86		VPS24_YEAST (8-196): 2.23e-31: 115: 17.90
+	Hs
		208873 UBP15_HUMAN (964-1106): 1.96e-34: 145: 49.65		CHM2A_HUMAN (1-177): 4.66e-38: 132: 24.29
+	Hs
		1316089 UBP15_HUMAN (964-1106): 1.96e-34: 145: 49.65		CHM4A_HUMAN (2-196): 6.68e-17: 77.4: 16.51