HitPredict

Interactor 1: LCB2 (P40970)
Serine palmitoyltransferase 2 (SPT 2) (EC 2.3.1.50) (Long chain base biosynthesis protein 2)
Gene: LCB2

Interactor 2: ORM1 (P53224)
Protein ORM1
Gene: ORM1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	20182505, 23363605
Identification Methods	anti tag coimmunoprecipitation, affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Aminotran_1_2~ORMDL
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0030148 - sphingolipid biosynthetic process GO:0090156 - intracellular sphingolipid homeostasis
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 561 Sc			1 222
+	Sc
		778675 LCB2_YEAST (1-561): 0: 834: 100.00		ORM2_YEAST (20-222): 8.62e-95: 277: 71.43
+	Sc
		626002 SPTC1_YEAST (144-475): 2.34e-99: 313: 24.93		ORM1_YEAST (1-222): 6.5e-112: 321: 100.00
+	Sc
		626008 SPTC1_YEAST (144-475): 2.34e-99: 313: 24.93		ORM2_YEAST (20-222): 8.62e-95: 277: 71.43
+	At
		1278265 SPTC1_ARATH (156-526): 1.8e-120: 365: 24.28		Q9C5I0_ARATH (74-210): 1.75e-69: 211: 34.31
+	At
		1278266 SPTC1_ARATH (156-526): 1.8e-120: 365: 24.28		Q9FHY3_ARATH (74-210): 1.98e-67: 206: 34.31
+	Hs
		174108 SPTC1_HUMAN (156-522): 5.92e-119: 361: 27.94		ORML3_HUMAN (74-210): 6.06e-65: 199: 37.68
+	Hs
		174163 SPTC1_HUMAN (156-522): 5.92e-119: 361: 27.94		ORML1_HUMAN (74-210): 1.52e-64: 198: 34.78
+	Hs
		174090 SPTC1_HUMAN (156-522): 5.92e-119: 361: 27.94		ORML2_HUMAN (74-210): 4.32e-64: 197: 35.51