HitPredict

Interactor 1: ID3 (P41133)
DNA-binding protein inhibitor ID-3 (ID-like protein inhibitor HLH 462) (Inhibitor of DNA binding 3) (Inhibitor of differentiation 3)
Gene: ID3

Interactor 2: ITF2 (Q60722)
Transcription factor 4 (TCF-4) (Class A helix-loop-helix transcription factor ME2) (Immunoglobulin transcription factor 2) (ITF-2) (MITF-2) (SL3-3 enhancer factor 2) (SEF-2)
Gene: Tcf4

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	1.00	0.757

Property	Details
Experiments	8759016, 20211142
Identification Methods	pull down, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0010629 - negative regulation of gene expression GO:0030154 - cell differentiation GO:0043425 - bHLH transcription factor binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 119 Mm			1 670
+	Hs
		551119 ID3_HUMAN (1-119): 9.85e-65: 193: 96.64		ITF2_HUMAN (1-670): 0: 891: 97.32
+	Mm
		781006 ID2_MOUSE (1-118): 4.51e-42: 136: 39.13		ITF2_MOUSE (1-670): 0: 927: 100.00
+	Hs
		551084 ID1_HUMAN (1-100): 2.57e-43: 140: 47.22		ITF2_HUMAN (1-670): 0: 891: 97.32
+	Hs
		551118 ID2_HUMAN (1-118): 1.49e-42: 137: 39.86		ITF2_HUMAN (1-670): 0: 891: 97.32
+	Hs
		971137 ID3_HUMAN (1-119): 9.85e-65: 193: 96.64		HTF4_HUMAN (3-670): 0: 787: 62.52
+	Mm
		780945 ID3_MOUSE (1-119): 2.86e-63: 189: 100.00		HTF4_MOUSE (3-670): 0: 778: 59.72
+	Hs
		780982 ID1_HUMAN (1-100): 2.57e-43: 140: 47.22		HTF4_HUMAN (3-670): 0: 787: 62.52
+	Hs
		970599 ID2_HUMAN (1-118): 1.49e-42: 137: 39.86		HTF4_HUMAN (3-670): 0: 787: 62.52
+	Hs
		551503 ID3_HUMAN (1-119): 9.85e-65: 193: 96.64		TFE2_HUMAN (1-670): 0: 721: 50.36
+	Mm
		781007 ID2_MOUSE (1-118): 4.51e-42: 136: 39.13		HTF4_MOUSE (3-670): 0: 778: 59.72
+	Rn
		600264 ID3_RAT (1-119): 2.56e-63: 189: 99.16		TFE2_RAT (1-670): 0: 703: 48.28
+	Mm
		780947 ID3_MOUSE (1-119): 2.86e-63: 189: 100.00		Q91XK1_MOUSE (182-670): 0: 688: 99.80
+	Mm
		550183 ID3_MOUSE (1-119): 2.86e-63: 189: 100.00		TFE2_MOUSE (1-670): 0: 685: 48.49
+	Hs
		551478 ID1_HUMAN (1-100): 2.57e-43: 140: 47.22		TFE2_HUMAN (1-670): 0: 721: 50.36
+	Hs
		551502 ID2_HUMAN (1-118): 1.49e-42: 137: 39.86		TFE2_HUMAN (1-670): 0: 721: 50.36
+	Mm
		781009 ID2_MOUSE (1-118): 4.51e-42: 136: 39.13		Q91XK1_MOUSE (182-670): 0: 688: 99.80
+	Mm
		589142 ID1_MOUSE (3-100): 7.62e-41: 134: 46.60		Q91XK1_MOUSE (182-670): 0: 688: 99.80
+	Mm
		550184 ID2_MOUSE (1-118): 4.51e-42: 136: 39.13		TFE2_MOUSE (1-670): 0: 685: 48.49
+	Mm
		550178 ID1_MOUSE (3-100): 7.62e-41: 134: 46.60		TFE2_MOUSE (1-670): 0: 685: 48.49
+	Hs
		111607 ID1_HUMAN (1-100): 2.57e-43: 140: 47.22		K7EMM4_HUMAN (440-670): 4.49e-97: 299: 53.85