HitPredict

Interactor 1: ID1 (P41134)
DNA-binding protein inhibitor ID-1 (Class B basic helix-loop-helix protein 24) (bHLHb24) (Inhibitor of DNA binding 1) (Inhibitor of differentiation 1)
Gene: ID1

Interactor 2: HTF4 (Q99081)
Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4)
Gene: TCF12

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	1.00	0.941

Property	Details
Experiments	26496610, 32296183, 9242638, 35440621, unassigned1304, 20211142
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0030154 - cell differentiation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 155 Hs			1 682
+	Mm
		1142448 Q6GTZ3_MOUSE (15-155): 1.41e-70: 211: 90.78		HTF4_MOUSE (1-682): 0: 907: 92.21
+	Hs
		971137 ID3_HUMAN (19-128): 1.94e-45: 146: 47.27		HTF4_HUMAN (1-682): 0: 921: 100.00
+	Mm
		781007 ID2_MOUSE (19-154): 3.1e-46: 148: 41.38		HTF4_MOUSE (1-682): 0: 907: 92.21
+	Mm
		780945 ID3_MOUSE (19-128): 8.16e-46: 147: 46.36		HTF4_MOUSE (1-682): 0: 907: 92.21
+	Mm
		1141284 Q6GTZ3_MOUSE (15-155): 1.41e-70: 211: 90.78		ITF2_MOUSE (2-682): 0: 804: 62.82
+	Hs
		551084 ID1_HUMAN (1-155): 1.17e-77: 229: 100.00		ITF2_HUMAN (2-682): 0: 777: 62.01
+	Hs
		551478 ID1_HUMAN (1-155): 1.17e-77: 229: 100.00		TFE2_HUMAN (2-682): 0: 753: 48.93
+	Mm
		781006 ID2_MOUSE (19-154): 3.1e-46: 148: 41.38		ITF2_MOUSE (2-682): 0: 804: 62.82
+	Mm
		780944 ID3_MOUSE (19-128): 8.16e-46: 147: 46.36		ITF2_MOUSE (2-682): 0: 804: 62.82
+	Mm
		550218 Q6GTZ3_MOUSE (15-155): 1.41e-70: 211: 90.78		TFE2_MOUSE (1-682): 0: 732: 49.43
+	Mm
		550178 ID1_MOUSE (15-142): 2.25e-63: 193: 89.84		TFE2_MOUSE (1-682): 0: 732: 49.43
+	Hs
		551119 ID3_HUMAN (19-128): 1.94e-45: 146: 47.27		ITF2_HUMAN (2-682): 0: 777: 62.01
+	Hs
		551503 ID3_HUMAN (19-128): 1.94e-45: 146: 47.27		TFE2_HUMAN (2-682): 0: 753: 48.93
+	Rn
		600264 ID3_RAT (19-128): 2.16e-45: 146: 46.36		TFE2_RAT (1-682): 0: 752: 49.14
+	Mm
		550184 ID2_MOUSE (19-154): 3.1e-46: 148: 41.38		TFE2_MOUSE (1-682): 0: 732: 49.43
+	Mm
		550183 ID3_MOUSE (19-128): 8.16e-46: 147: 46.36		TFE2_MOUSE (1-682): 0: 732: 49.43
+	Mm
		589142 ID1_MOUSE (15-142): 2.25e-63: 193: 89.84		Q91XK1_MOUSE (193-682): 0: 601: 65.41
+	Mm
		781009 ID2_MOUSE (19-154): 3.1e-46: 148: 41.38		Q91XK1_MOUSE (193-682): 0: 601: 65.41
+	Mm
		780947 ID3_MOUSE (19-128): 8.16e-46: 147: 46.36		Q91XK1_MOUSE (193-682): 0: 601: 65.41
+	Hs
		111607 ID1_HUMAN (1-155): 1.17e-77: 229: 100.00		K7EMM4_HUMAN (455-682): 1.04e-97: 301: 52.16