HitPredict

Interactor 1: ID1 (P41134)
DNA-binding protein inhibitor ID-1 (Class B basic helix-loop-helix protein 24) (bHLHb24) (Inhibitor of DNA binding 1) (Inhibitor of differentiation 1)
Gene: ID1

Interactor 2: ASCL3 (Q9NQ33)
Achaete-scute homolog 3 (ASH-3) (hASH3) (Class A basic helix-loop-helix protein 42) (bHLHa42) (bHLH transcriptional regulator Sgn-1)
Gene: ASCL3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid array, validated two hybrid, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0046983 - protein dimerization activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 155 Hs			1 181
+	Hs
		551478 ID1_HUMAN (1-155): 1.17e-77: 229: 100.00		TFE2_HUMAN (5-178): 2.08e-28: 112: 17.42
+	Hs
		111607 ID1_HUMAN (1-155): 1.17e-77: 229: 100.00		K7EMM4_HUMAN (5-178): 1.28e-29: 109: 16.57
+	Hs
		526742 ID1_HUMAN (1-155): 1.17e-77: 229: 100.00		MYF5_HUMAN (32-179): 3.3e-28: 107: 22.15
+	Hs
		524547 ID1_HUMAN (1-155): 1.17e-77: 229: 100.00		LYL1_HUMAN (6-169): 5.54e-27: 104: 26.19
+	Hs
		780971 ID1_HUMAN (1-155): 1.17e-77: 229: 100.00		ASCL4_HUMAN (14-172): 1.54e-27: 103: 37.11
+	Mm
		589139 ID1_MOUSE (15-142): 2.25e-63: 193: 89.84		TAL1_MOUSE (53-162): 1.43e-26: 104: 35.00
+	Hs
		814914 ID4_HUMAN (19-155): 1.46e-32: 114: 34.94		ASCL3_HUMAN (1-181): 3.09e-52: 166: 100.00
+	Hs
		551502 ID2_HUMAN (19-154): 3.39e-45: 146: 42.07		TFE2_HUMAN (5-178): 2.08e-28: 112: 17.42
+	Hs
		551503 ID3_HUMAN (19-128): 1.94e-45: 146: 47.27		TFE2_HUMAN (5-178): 2.08e-28: 112: 17.42
+	Hs
		526743 ID2_HUMAN (19-154): 3.39e-45: 146: 42.07		MYF5_HUMAN (32-179): 3.3e-28: 107: 22.15
+	Hs
		526744 ID3_HUMAN (19-128): 1.94e-45: 146: 47.27		MYF5_HUMAN (32-179): 3.3e-28: 107: 22.15
+	Hs
		524557 ID3_HUMAN (19-128): 1.94e-45: 146: 47.27		LYL1_HUMAN (6-169): 5.54e-27: 104: 26.19
+	Hs
		970583 ID2_HUMAN (19-154): 3.39e-45: 146: 42.07		ASCL4_HUMAN (14-172): 1.54e-27: 103: 37.11
+	Hs
		551480 ID4_HUMAN (19-155): 1.46e-32: 114: 34.94		TFE2_HUMAN (5-178): 2.08e-28: 112: 17.42
+	Hs
		616610 ID4_HUMAN (19-155): 1.46e-32: 114: 34.94		MYF6_HUMAN (29-157): 5.89e-29: 109: 27.14
+	Hs
		568188 ID4_HUMAN (19-155): 1.46e-32: 114: 34.94		TAL1_HUMAN (53-158): 3.16e-27: 106: 35.35
+	Hs
		524549 ID4_HUMAN (19-155): 1.46e-32: 114: 34.94		LYL1_HUMAN (6-169): 5.54e-27: 104: 26.19
+	Hs
		814916 ID4_HUMAN (19-155): 1.46e-32: 114: 34.94		NGN3_HUMAN (23-176): 1.56e-27: 104: 20.96
+	Hs
		238590 ID2_HUMAN (19-154): 3.39e-45: 146: 42.07		MUSC_HUMAN (83-157): 1.2e-12: 65.2: 30.67
+	Dm
		485888 EMC_DROME (68-134): 3.59e-23: 91.8: 47.76		AST5_DROME (91-153): 2.67e-20: 85.2: 41.56