HitPredict

Interactor 1: BCL6 (P41182)
B-cell lymphoma 6 protein (BCL-6) (B-cell lymphoma 5 protein) (BCL-5) (Protein LAZ-3) (Zinc finger and BTB domain-containing protein 27) (Zinc finger protein 51)
Gene: BCL6

Interactor 2: NACC1 (Q96RE7)
Nucleus accumbens-associated protein 1 (NAC-1) (BTB/POZ domain-containing protein 14B)
Gene: NACC1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	1.00	0.713

Property	Details
Experiments	19121354
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	BTB~BTB
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 706 Hs			1 527
+	Hs
		781493 BCL6_HUMAN (1-706): 0: 542: 100.00		KLH20_HUMAN (4-267): 7.84e-69: 234: 17.47
+	Hs
		781380 BCL6_HUMAN (1-706): 0: 542: 100.00		KLH12_HUMAN (10-268): 5.89e-67: 227: 18.63
+	Hs
		312029 BCL6_HUMAN (1-706): 0: 542: 100.00		ZBT7A_HUMAN (1-431): 6.26e-61: 212: 16.86
+	Hs
		781378 BCL6_HUMAN (1-706): 0: 542: 100.00		ZBTB6_HUMAN (2-432): 5.68e-59: 203: 16.52
+	Hs
		781317 BCL6_HUMAN (1-706): 0: 542: 100.00		BCL6_HUMAN (6-350): 2.1e-49: 182: 19.07
+	Mm
		781499 BCL6_MOUSE (1-706): 1.16e-180: 533: 94.63		BCL6_MOUSE (6-350): 1.92e-52: 191: 19.35
+	Hs
		781345 BCL6_HUMAN (1-706): 0: 542: 100.00		ZBT16_HUMAN (4-346): 1.57e-48: 180: 20.52
+	Hs
		781357 BCL6_HUMAN (1-706): 0: 542: 100.00		ZBT17_HUMAN (7-365): 4.44e-45: 171: 20.89
+	Hs
		169701 BCL6_HUMAN (1-706): 0: 542: 100.00		ZBT7B_HUMAN (2-354): 3.46e-44: 165: 17.30
+	Hs
		781438 BCL6_HUMAN (1-706): 0: 542: 100.00		Q9BS75_HUMAN (4-160): 1.97e-45: 161: 24.22
+	Hs
		781446 BCL6_HUMAN (1-706): 0: 542: 100.00		BACH2_HUMAN (2-268): 2.44e-41: 160: 20.74
+	Hs
		66758 BCL6_HUMAN (1-706): 0: 542: 100.00		A8KA13_HUMAN (8-277): 1.25e-41: 157: 20.68
+	Hs
		781395 BCL6_HUMAN (1-706): 0: 542: 100.00		BCL6B_HUMAN (8-277): 1.56e-41: 157: 20.75
+	Mm
		781500 BCL6_MOUSE (1-706): 1.16e-180: 533: 94.63		BACH2_MOUSE (2-265): 2.56e-42: 163: 22.10
+	Mm
		291331 BCL6_MOUSE (1-706): 1.16e-180: 533: 94.63		BCL6B_MOUSE (8-277): 3e-42: 159: 19.78
+	Hs
		1024287 ZBT17_HUMAN (445-695): 3.46e-93: 308: 28.24		ZBT17_HUMAN (7-365): 4.44e-45: 171: 20.89
+	Hs
		1024297 ZBT17_HUMAN (445-695): 3.46e-93: 308: 28.24		ZBT8A_HUMAN (7-188): 1.37e-41: 156: 26.09
+	Hs
		1024291 ZBT17_HUMAN (445-695): 3.46e-93: 308: 28.24		ZBT49_HUMAN (16-113): 5.01e-13: 73.9: 45.55
+	Hs
		51226 ZBT17_HUMAN (445-695): 3.46e-93: 308: 28.24		ZBT7C_HUMAN (3-114): 3.75e-13: 73.9: 38.21