HitPredict

Interactor 1: TRAF6 (B5DF45)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Interactor 2: NTRK1 (P35739)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (Slow nerve growth factor receptor) (p140-TrkA) (Trk-A)
Gene: NTRK1

Species: Rattus norvegicus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	25708205, 16246731
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0032991 - protein-containing complex GO:0051092 - positive regulation of NF-kappaB transcription factor activity
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 530 Rn			1 799
+	Mm
		936225 TRAF6_MOUSE (1-530): 3.87e-148: 437: 95.85		NTRK1_MOUSE (1-799): 0: 662: 96.25
+	Hs
		385784 TRAF6_HUMAN (1-530): 1.02e-150: 443: 86.42		NTRK1_HUMAN (1-799): 0: 640: 85.73
+	Hs
		1083913 TRAF6_HUMAN (1-530): 1.02e-150: 443: 86.42		NTRK2_HUMAN (10-799): 0: 542: 46.87
+	Hs
		385449 TRAF4_HUMAN (54-515): 1.91e-99: 310: 25.90		NTRK1_HUMAN (1-799): 0: 640: 85.73
+	Hs
		508289 TRAF6_HUMAN (1-530): 1.02e-150: 443: 86.42		FGFR1_HUMAN (192-798): 5.88e-166: 502: 26.21
+	Hs
		1031182 TRAF6_HUMAN (1-530): 1.02e-150: 443: 86.42		PTK7_HUMAN (201-784): 9.1e-154: 478: 27.49
+	Mm
		548981 TR30A_MOUSE (56-417): 2.57e-47: 173: 14.32		NTRK1_MOUSE (1-799): 0: 662: 96.25
+	Hs
		872432 TRAF2_HUMAN (38-508): 1.05e-106: 330: 27.15		EPHA5_HUMAN (412-794): 2.26e-112: 368: 29.37
+	Hs
		584931 RO52_HUMAN (61-418): 6.53e-61: 209: 13.46		ROR1_HUMAN (518-786): 1.55e-72: 257: 47.62
+	Hs
		435641 TRI25_HUMAN (63-387): 2.71e-40: 156: 13.51		IGF1R_HUMAN (496-780): 7.95e-70: 252: 41.92
+	Hs
		1087823 MEP1B_HUMAN (347-526): 5.81e-42: 161: 20.50		ALK_HUMAN (508-791): 2.34e-64: 236: 42.71
+	Hs
		435761 RNF41_HUMAN (55-281): 1.22e-23: 103: 24.03		IGF1R_HUMAN (496-780): 7.95e-70: 252: 41.92
+	Hs
		411494 RNF41_HUMAN (55-281): 1.22e-23: 103: 24.03		INSR_HUMAN (496-780): 1.53e-67: 246: 41.95
+	Hs
		169214 PZRN3_HUMAN (55-273): 7.24e-35: 142: 21.15		MUSK_HUMAN (175-380): 1.77e-12: 73.1: 18.81