HitPredict

Interactor 1: CUL3 (B5DF89)
Cullin-3
Gene: CUL3

Interactor 2: UBC (Q63429)
Polyubiquitin-C [Cleaved into: Ubiquitin; Ubiquitin-related]
Gene: UBC

Species: Rattus norvegicus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22871113
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Cullin~ubiquitin, Cullin_Nedd8~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0006511 - ubiquitin-dependent protein catabolic process GO:0016567 - protein ubiquitination GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 768 Rn			1 810
+	Rn
		71349 B2RYJ3_RAT (5-768): 0: 798: 37.68		UBC_RAT (1-810): 0: 1000: 100.00
+	Rn
		70071 B1WBY1_RAT (17-768): 0: 706: 29.90		UBC_RAT (1-810): 0: 1000: 100.00
+	Hs
		475728 CUL3_HUMAN (1-768): 0: 942: 99.61		UBC_HUMAN (1-533): 0: 662: 99.81
+	Rn
		1144279 CUL5_RAT (25-768): 0: 595: 23.40		UBC_RAT (1-810): 0: 1000: 100.00
+	Hs
		475729 CUL4A_HUMAN (10-768): 0: 796: 38.45		UBC_HUMAN (1-533): 0: 662: 99.81
+	Hs
		475730 CUL4B_HUMAN (5-768): 0: 789: 36.77		UBC_HUMAN (1-533): 0: 662: 99.81
+	Hs
		475726 CUL1_HUMAN (18-768): 0: 705: 29.94		UBC_HUMAN (1-533): 0: 662: 99.81
+	Hs
		475727 CUL2_HUMAN (30-768): 0: 667: 26.30		UBC_HUMAN (1-533): 0: 662: 99.81
+	Hs
		923983 CUL3_HUMAN (1-768): 0: 942: 99.61		RS27A_HUMAN (685-760): 5.08e-42: 152: 100.00
+	Mm
		477034 CUL3_MOUSE (1-768): 0: 942: 99.87		UBC_MOUSE (1-108): 6.19e-31: 132: 90.74
+	Sp
		142914 CUL1_SCHPO (15-768): 0: 669: 28.29		UBI4P_SCHPO (457-801): 1.39e-132: 401: 90.73
+	At
		1091919 CUL1_ARATH (16-768): 0: 723: 30.22		UBQ3_ARATH (533-801): 1.64e-106: 330: 89.22
+	At
		1352191 CUL3A_ARATH (9-768): 0: 840: 51.32		RUB1_ARATH (685-801): 2.07e-38: 142: 72.65
+	At
		1321116 CUL3B_ARATH (9-768): 0: 823: 50.79		RUB1_ARATH (685-801): 2.07e-38: 142: 72.65
+	Hs
		923984 CUL4A_HUMAN (10-768): 0: 796: 38.45		RS27A_HUMAN (685-760): 5.08e-42: 152: 100.00
+	Hs
		923985 CUL4B_HUMAN (5-768): 0: 789: 36.77		RS27A_HUMAN (685-760): 5.08e-42: 152: 100.00
+	Hs
		475024 CUL4B_HUMAN (5-768): 0: 789: 36.77		UBB_HUMAN (1-77): 1.17e-26: 110: 98.70
+	At
		1277343 CUL1_ARATH (16-768): 0: 723: 30.22		RUB1_ARATH (685-801): 2.07e-38: 142: 72.65
+	At
		1247030 CUL1_ARATH (16-768): 0: 723: 30.22		RUB2_ARATH (685-801): 5.81e-38: 140: 72.65
+	Mm
		477001 CUL2_MOUSE (30-768): 0: 675: 26.17		UBC_MOUSE (1-108): 6.19e-31: 132: 90.74