HitPredict

Interactor 1: CUL3 (B5DF89)
Cullin-3
Gene: CUL3

Interactor 2: KLH17 (Q8K430)
Kelch-like protein 17 (Actinfilin)
Gene: Klhl17

Species: Rattus norvegicus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17062563
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	BACK~Cullin, BTB~Cullin
Common GO terms	GO:0016567 - protein ubiquitination GO:0031208 - POZ domain binding GO:0098794 - postsynapse GO:0098978 - glutamatergic synapse GO:0140252 - regulation protein catabolic process at postsynapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 768 Rn			1 640
+	Hs
		1041852 CUL3_HUMAN (1-768): 0: 942: 99.61		KLH17_HUMAN (1-640): 0: 542: 97.04
+	Hs
		1042324 CUL3_HUMAN (1-768): 0: 942: 99.61		KLHL5_HUMAN (53-621): 1.36e-169: 503: 42.09
+	Hs
		1041712 CUL3_HUMAN (1-768): 0: 942: 99.61		KLH12_HUMAN (70-623): 1.8e-171: 502: 40.75
+	Hs
		1042624 CUL3_HUMAN (1-768): 0: 942: 99.61		KLHL1_HUMAN (21-621): 6.63e-167: 497: 39.19
+	Hs
		299515 CUL3_HUMAN (1-768): 0: 942: 99.61		KLH18_HUMAN (62-620): 2.13e-164: 484: 42.86
+	Hs
		1042720 CUL3_HUMAN (1-768): 0: 942: 99.61		KLHL8_HUMAN (32-622): 4.84e-161: 477: 34.91
+	Hs
		1042674 CUL3_HUMAN (1-768): 0: 942: 99.61		KLH28_HUMAN (59-620): 2.19e-157: 466: 39.83
+	Hs
		1041807 CUL3_HUMAN (1-768): 0: 942: 99.61		KLH10_HUMAN (78-622): 4.6e-155: 461: 34.49
+	Hs
		1042489 CUL3_HUMAN (1-768): 0: 942: 99.61		KLHL4_HUMAN (50-621): 1.3e-153: 461: 39.45
+	Mm
		1322059 CUL3_MOUSE (1-768): 0: 942: 99.87		KLH10_MOUSE (78-622): 3.71e-154: 459: 34.49
+	Hs
		1042026 CUL3_HUMAN (1-768): 0: 942: 99.61		Q8N4I8_HUMAN (72-333): 5.77e-96: 298: 53.61
+	Hs
		1042027 CUL3_HUMAN (1-768): 0: 942: 99.61		KLH36_HUMAN (418-640): 6.1e-43: 165: 24.89
+	Hs
		1041547 CUL3_HUMAN (1-768): 0: 942: 99.61		KEAP1_HUMAN (468-639): 8.99e-36: 144: 30.11
+	Mm
		1337550 CUL3_MOUSE (1-768): 0: 942: 99.87		KEAP1_MOUSE (479-639): 2.72e-34: 140: 30.30
+	Hs
		1041853 CUL3_HUMAN (1-768): 0: 942: 99.61		KLH24_HUMAN (462-640): 1.18e-33: 138: 24.18
+	Mm
		1225041 CUL3_MOUSE (1-768): 0: 942: 99.87		KLHL2_MOUSE (529-638): 8.17e-22: 101: 31.82
+	Hs
		307170 CUL3_HUMAN (1-768): 0: 942: 99.61		KLHL2_HUMAN (529-638): 7.34e-22: 101: 31.82
+	Hs
		1042167 CUL3_HUMAN (1-768): 0: 942: 99.61		KLHL6_HUMAN (49-481): 3.23e-16: 84.1: 12.78
+	Hs
		1042508 CUL3_HUMAN (1-768): 0: 942: 99.61		KLH25_HUMAN (527-640): 6.24e-14: 77: 19.49
+	Hs
		1041986 CUL3_HUMAN (1-768): 0: 942: 99.61		KLHL7_HUMAN (444-621): 2.5e-13: 75.1: 27.96