HitPredict

Interactor 1: RGS2 (P41220)
Regulator of G-protein signaling 2 (RGS2) (Cell growth-inhibiting gene 31 protein) (G0/G1 switch regulatory protein 8)
Gene: RGS2

Interactor 2: GNAQ (P50148)
Guanine nucleotide-binding protein G(q) subunit alpha (Guanine nucleotide-binding protein alpha-q)
Gene: GNAQ

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	12885252
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	G-alpha~RGS
Common GO terms	GO:0003924 - GTPase activity GO:0005096 - GTPase activator activity GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 211 Hs			1 359
+	Hs
		670435 RGS3_HUMAN (14-206): 8.22e-72: 238: 46.11		GNA11_HUMAN (1-359): 6.04e-170: 479: 90.25
+	Hs
		391357 RGS3_HUMAN (14-206): 8.22e-72: 238: 46.11		GNAI2_HUMAN (7-358): 4.08e-166: 469: 50.42
+	Hs
		444692 RGS3_HUMAN (14-206): 8.22e-72: 238: 46.11		GNAI3_HUMAN (7-358): 3.79e-165: 467: 51.13
+	Hs
		444680 RGS2_HUMAN (1-211): 4.66e-76: 229: 100.00		GNAI3_HUMAN (7-358): 3.79e-165: 467: 51.13
+	Mm
		597637 RGS18_MOUSE (3-200): 7.54e-64: 199: 44.00		GNAQ_MOUSE (1-359): 2.21e-175: 492: 99.72
+	Hs
		837653 RGS18_HUMAN (3-200): 3.1e-63: 197: 42.37		GNAQ_HUMAN (1-359): 4.22e-175: 492: 100.00
+	Hs
		283183 RGS20_HUMAN (12-209): 3.6e-66: 210: 29.85		GNAI1_HUMAN (7-358): 4.95e-168: 474: 52.26
+	Hs
		283160 RGS20_HUMAN (12-209): 3.6e-66: 210: 29.85		GNAO_HUMAN (7-358): 2.12e-167: 472: 50.57
+	Hs
		283156 RGS20_HUMAN (12-209): 3.6e-66: 210: 29.85		GNAI2_HUMAN (7-358): 4.08e-166: 469: 50.42
+	Hs
		926720 RGS18_HUMAN (3-200): 3.1e-63: 197: 42.37		GNAI1_HUMAN (7-358): 4.95e-168: 474: 52.26
+	Hs
		450988 RGS19_HUMAN (13-210): 3.56e-63: 196: 29.80		GNAO_HUMAN (7-358): 2.12e-167: 472: 50.57
+	Hs
		391473 RGS18_HUMAN (3-200): 3.1e-63: 197: 42.37		GNAI2_HUMAN (7-358): 4.08e-166: 469: 50.42
+	Hs
		391356 RGS19_HUMAN (13-210): 3.56e-63: 196: 29.80		GNAI2_HUMAN (7-358): 4.08e-166: 469: 50.42
+	Hs
		444800 RGS18_HUMAN (3-200): 3.1e-63: 197: 42.37		GNAI3_HUMAN (7-358): 3.79e-165: 467: 51.13
+	Hs
		444691 RGS19_HUMAN (13-210): 3.56e-63: 196: 29.80		GNAI3_HUMAN (7-358): 3.79e-165: 467: 51.13
+	Mm
		1307938 RGS18_MOUSE (3-200): 7.54e-64: 199: 44.00		GNAI3_MOUSE (7-358): 8.01e-164: 463: 50.85
+	Hs
		782024 RGS2_HUMAN (1-211): 4.66e-76: 229: 100.00		GNAS2_HUMAN (7-359): 1e-148: 426: 38.07
+	Hs
		675585 RGS2_HUMAN (1-211): 4.66e-76: 229: 100.00		GNA15_HUMAN (10-359): 1.38e-148: 425: 55.25
+	Hs
		283162 RGS20_HUMAN (12-209): 3.6e-66: 210: 29.85		GNAZ_HUMAN (7-358): 2.4e-150: 429: 47.89
+	Hs
		580409 RGS19_HUMAN (13-210): 3.56e-63: 196: 29.80		GNAZ_HUMAN (7-358): 2.4e-150: 429: 47.89