HitPredict

Interactor 1: RGS2 (P41220)
Regulator of G-protein signaling 2 (RGS2) (Cell growth-inhibiting gene 31 protein) (G0/G1 switch regulatory protein 8)
Gene: RGS2

Interactor 2: GNAS2 (P63092)
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (Adenylate cyclase-stimulating G alpha protein)
Gene: GNAS

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	9794454
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	G-alpha~RGS
Common GO terms	GO:0003924 - GTPase activity GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 211 Hs			1 394
+	Hs
		391357 RGS3_HUMAN (14-206): 8.22e-72: 238: 46.11		GNAI2_HUMAN (1-394): 1.99e-158: 451: 38.83
+	Hs
		444692 RGS3_HUMAN (14-206): 8.22e-72: 238: 46.11		GNAI3_HUMAN (1-394): 1.06e-155: 444: 38.58
+	Hs
		444680 RGS2_HUMAN (1-211): 4.66e-76: 229: 100.00		GNAI3_HUMAN (1-394): 1.06e-155: 444: 38.58
+	Hs
		283156 RGS20_HUMAN (12-209): 3.6e-66: 210: 29.85		GNAI2_HUMAN (1-394): 1.99e-158: 451: 38.83
+	Hs
		782018 RGS2_HUMAN (1-211): 4.66e-76: 229: 100.00		GNAQ_HUMAN (11-394): 9.45e-151: 432: 38.02
+	Hs
		283183 RGS20_HUMAN (12-209): 3.6e-66: 210: 29.85		GNAI1_HUMAN (1-394): 5.37e-158: 450: 39.09
+	Hs
		670435 RGS3_HUMAN (14-206): 8.22e-72: 238: 46.11		GNA11_HUMAN (11-394): 1.04e-146: 421: 38.80
+	Hs
		283160 RGS20_HUMAN (12-209): 3.6e-66: 210: 29.85		GNAO_HUMAN (1-394): 2.43e-153: 438: 40.66
+	Hs
		391473 RGS18_HUMAN (3-200): 3.1e-63: 197: 42.37		GNAI2_HUMAN (1-394): 1.99e-158: 451: 38.83
+	Hs
		391356 RGS19_HUMAN (13-210): 3.56e-63: 196: 29.80		GNAI2_HUMAN (1-394): 1.99e-158: 451: 38.83
+	Hs
		926720 RGS18_HUMAN (3-200): 3.1e-63: 197: 42.37		GNAI1_HUMAN (1-394): 5.37e-158: 450: 39.09
+	Hs
		444800 RGS18_HUMAN (3-200): 3.1e-63: 197: 42.37		GNAI3_HUMAN (1-394): 1.06e-155: 444: 38.58
+	Hs
		444691 RGS19_HUMAN (13-210): 3.56e-63: 196: 29.80		GNAI3_HUMAN (1-394): 1.06e-155: 444: 38.58
+	Mm
		1307938 RGS18_MOUSE (3-200): 7.54e-64: 199: 44.00		GNAI3_MOUSE (1-394): 1.35e-153: 439: 38.07
+	Hs
		450988 RGS19_HUMAN (13-210): 3.56e-63: 196: 29.80		GNAO_HUMAN (1-394): 2.43e-153: 438: 40.66
+	Mm
		597637 RGS18_MOUSE (3-200): 7.54e-64: 199: 44.00		GNAQ_MOUSE (11-394): 5.78e-151: 432: 38.02
+	Hs
		837653 RGS18_HUMAN (3-200): 3.1e-63: 197: 42.37		GNAQ_HUMAN (11-394): 9.45e-151: 432: 38.02
+	Hs
		283162 RGS20_HUMAN (12-209): 3.6e-66: 210: 29.85		GNAZ_HUMAN (1-393): 2.98e-142: 410: 37.15
+	Hs
		580409 RGS19_HUMAN (13-210): 3.56e-63: 196: 29.80		GNAZ_HUMAN (1-393): 2.98e-142: 410: 37.15
+	Hs
		675585 RGS2_HUMAN (1-211): 4.66e-76: 229: 100.00		GNA15_HUMAN (9-394): 1.58e-77: 245: 36.71