HitPredict

Interactor 1: UBA7 (P41226)
Ubiquitin-like modifier-activating enzyme 7 (Ubiquitin-activating enzyme 7) (EC 6.2.1.-) (D8) (Ubiquitin-activating enzyme E1 homolog)
Gene: UBA7

Interactor 2: UB2E1 (P51965)
Ubiquitin-conjugating enzyme E2 E1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme E1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme E1) (UbcH6) (Ubiquitin carrier protein E1) (Ubiquitin-protein ligase E1)
Gene: UBE2E1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	16428300
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	E1_UFD~UQ_con, ThiF~UQ_con
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005524 - ATP binding GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0016567 - protein ubiquitination and 1 others more... GO:0032020 - ISG15-protein conjugation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1012 Hs			1 193
+	Hs
		607136 UBA1_HUMAN (1-1012): 0: 1216: 45.70		UB2E2_HUMAN (4-193): 2.5e-84: 249: 81.96
+	Hs
		607028 UBA1_HUMAN (1-1012): 0: 1216: 45.70		UB2E1_HUMAN (19-193): 2.75e-82: 244: 100.00
+	Hs
		607190 UBA1_HUMAN (1-1012): 0: 1216: 45.70		UB2D4_HUMAN (47-192): 2.38e-81: 239: 63.01
+	Hs
		607050 UBA1_HUMAN (1-1012): 0: 1216: 45.70		UB2D2_HUMAN (47-192): 8.03e-81: 238: 64.38
+	Hs
		607026 UBA1_HUMAN (1-1012): 0: 1216: 45.70		UB2D1_HUMAN (47-192): 3.02e-80: 237: 61.64
+	Hs
		607129 UBA1_HUMAN (1-1012): 0: 1216: 45.70		UB2E3_HUMAN (3-193): 1.26e-78: 235: 77.49
+	Hs
		607039 UBA1_HUMAN (1-1012): 0: 1216: 45.70		UB2D3_HUMAN (47-192): 2.56e-79: 234: 63.70
+	Hs
		607042 UBA1_HUMAN (1-1012): 0: 1216: 45.70		UBE2N_HUMAN (45-192): 8.9e-75: 223: 45.95
+	Hs
		607023 UBA1_HUMAN (1-1012): 0: 1216: 45.70		UBE2A_HUMAN (44-190): 1.1e-70: 212: 36.74
+	Hs
		607054 UBA1_HUMAN (1-1012): 0: 1216: 45.70		UBE2B_HUMAN (44-190): 1.31e-69: 210: 36.05
+	Sc
		549788 UBA1_YEAST (3-1008): 0: 1054: 37.04		UBC4_YEAST (46-192): 1.28e-79: 235: 63.95
+	Sp
		293848 UBA1_SCHPO (1-1008): 0: 1048: 37.71		UBC4_SCHPO (47-192): 2.61e-79: 234: 65.07
+	Dm
		715098 Q8T0L3_DROME (2-1012): 0: 1072: 40.10		UBE2N_DROME (45-192): 4.17e-69: 209: 45.27
+	Sc
		608714 UBA1_YEAST (3-1008): 0: 1054: 37.04		UBC13_YEAST (45-192): 6.73e-38: 129: 46.62
+	Sp
		142467 UBA1_SCHPO (1-1008): 0: 1048: 37.71		UBC13_SCHPO (50-192): 3.72e-38: 130: 47.55
+	Hs
		1282360 SAE2_HUMAN (20-388): 6.9e-82: 280: 16.79		UB2E3_HUMAN (3-193): 1.26e-78: 235: 77.49
+	Hs
		919796 UBA3_HUMAN (764-975): 3.13e-43: 166: 18.10		UB2D2_HUMAN (47-192): 8.03e-81: 238: 64.38
+	Hs
		48107 UBA6_HUMAN (402-572): 2.99e-23: 108: 21.71		UB2D2_HUMAN (47-192): 8.03e-81: 238: 64.38
+	Hs
		48104 UBA6_HUMAN (402-572): 2.99e-23: 108: 21.71		UB2D1_HUMAN (47-192): 3.02e-80: 237: 61.64
+	Hs
		48106 UBA6_HUMAN (402-572): 2.99e-23: 108: 21.71		UB2D3_HUMAN (47-192): 2.56e-79: 234: 63.70