HitPredict

Interactor 1: KDM5C (P41229)
Lysine-specific demethylase 5C (EC 1.14.11.67) (Histone demethylase JARID1C) (Jumonji/ARID domain-containing protein 1C) (Protein SmcX) (Protein Xe169) ([histone H3]-trimethyl-L-lysine(4) demethylase 5C)
Gene: KDM5C

Interactor 2: H32 (Q71DI3)
Histone H3.2 (H3-clustered histone 13) (H3-clustered histone 14) (H3-clustered histone 15) (Histone H3/m) (Histone H3/o)
Gene: H3C15

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.655

Property	Details
Experiments	17320161, 17320160, 17468742
Identification Methods	pull down, enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1560 Hs			1 136
+	Hs
		1086304 KDM5D_HUMAN (1-1557): 0: 1652: 83.95		H31T_HUMAN (1-136): 8.3e-62: 187: 96.32
+	Hs
		935339 KDM5B_HUMAN (7-1534): 0: 1416: 46.81		H31_HUMAN (1-136): 1.98e-62: 189: 99.27
+	Dm
		356114 KDM5_DROME (8-1556): 0: 1321: 40.53		H3_DROME (1-136): 3.73e-61: 186: 100.00
+	Sc
		812506 JHD2_YEAST (11-740): 2.02e-141: 454: 25.60		H3_YEAST (1-136): 7.77e-56: 172: 88.97
+	Hs
		183098 KDM6A_HUMAN (172-768): 1.23e-100: 356: 12.76		H31_HUMAN (1-136): 1.98e-62: 189: 99.27
+	Hs
		183122 KDM6A_HUMAN (172-768): 1.23e-100: 356: 12.76		H31T_HUMAN (1-136): 8.3e-62: 187: 96.32
+	Hs
		183127 KDM6A_HUMAN (172-768): 1.23e-100: 356: 12.76		H32_HUMAN (1-136): 3.73e-61: 186: 100.00
+	Dm
		356106 Q9VG78_DROME (1141-1554): 3.5e-91: 330: 15.68		H3_DROME (1-136): 3.73e-61: 186: 100.00
+	Hs
		301134 KDM4B_HUMAN (346-696): 1.9e-88: 315: 25.48		H31_HUMAN (1-136): 1.98e-62: 189: 99.27
+	Hs
		301136 KDM4B_HUMAN (346-696): 1.9e-88: 315: 25.48		H33_HUMAN (1-136): 1.59e-61: 186: 97.06
+	Hs
		301146 KDM4B_HUMAN (346-696): 1.9e-88: 315: 25.48		H3C_HUMAN (1-136): 8.83e-59: 179: 94.12
+	Hs
		935232 KDM4C_HUMAN (346-659): 2.66e-84: 302: 26.54		H31_HUMAN (1-136): 1.98e-62: 189: 99.27
+	Hs
		1174653 KDM4C_HUMAN (346-659): 2.66e-84: 302: 26.54		H32_HUMAN (1-136): 3.73e-61: 186: 100.00
+	Hs
		952622 KDM4C_HUMAN (346-659): 2.66e-84: 302: 26.54		H33_HUMAN (1-136): 1.59e-61: 186: 97.06
+	Hs
		256961 KDM4A_HUMAN (346-659): 1.73e-82: 297: 27.73		H31_HUMAN (1-136): 1.98e-62: 189: 99.27
+	Mm
		952745 KDM6B_MOUSE (199-769): 5.47e-82: 300: 12.64		H33_MOUSE (1-136): 1.59e-61: 186: 97.06
+	Hs
		256973 KDM4A_HUMAN (346-659): 1.73e-82: 297: 27.73		H31T_HUMAN (1-136): 8.3e-62: 187: 96.32
+	Hs
		256963 KDM4A_HUMAN (346-659): 1.73e-82: 297: 27.73		H33_HUMAN (1-136): 1.59e-61: 186: 97.06
+	Dm
		356098 KDM4B_DROME (346-661): 2.56e-84: 290: 25.77		H3_DROME (1-136): 3.73e-61: 186: 100.00
+	Dm
		356095 KDM4A_DROME (346-669): 2.73e-84: 287: 26.04		H3_DROME (1-136): 3.73e-61: 186: 100.00